Background Postinfarction cardiac remodeling presents a compensatory mechanism aimed
at mitigating congestive heart failure. It is distinguished by progressive dilatation and …

Objective We investigated the protective effect of icariin on myocardial infarction-induced
cardiac remodeling. Methods A cardiac remodeling model was constructed by ligating rats' …

Objectives In this study, the anti-heart failure effect of icariin, a natural flavonol glycoside,
and the underlying mechanisms were investigated. Methods Heart failure was induced by …

Studies have demonstrated that icariin plays important roles in preventing hypertension and
improving myocardial hypertrophy, inflammatory and infiltration. Icariside (ICS II) is the main …

It is well‐accepted that inflammation plays an important role in the development of cardiac
remodelling and that therapeutic approaches targeting inflammation can inhibit cardiac …

Objectives We aimed to investigate the effects of icariside II (ICS II) on myocardial fibrosis in
spontaneously hypertensive rats (SHRs) and to explore the possible mechanisms. Methods …

Background Inflammation plays a pathogenic role in the development of heart failure (HF).
The aim of this study was to examine the effect of treatment with the immunomodulating drug …

In this study, we aim to investigate the role of tanshinone IIA in myocardial infarction (MI),
especially in left ventricular remodelling (VR) and the underlying mechanism involving the …

Objective: Diabetic cardiomyopathy (DCM) is a serious complication of type 2 diabetes
mellitus (T2DM), resulting in unfavorable prognosis. Icariin (ICA) is a major flavonoid …

Introduction: Attenuating cardiac fibroblasts activation contributes to reducing excessive
extracellular matrix deposition and cardiac structural remodeling in hypertensive hearts …