Abstract Aims Trimethylamine-N-oxide (TMAO) is produced in host liver from trimethylamine
(TMA). TMAO and TMA share common dietary quaternary amine precursors, carnitine and …

L-carnitine, a nutrient in red meat, was recently reported to accelerate atherosclerosis via a
metaorganismal pathway involving gut microbial trimethylamine (TMA) formation and host …

Choline is metabolized by the gut microbiota into trimethylamine (TMA), the precursor of pro-
atherosclerotic molecule trimethylamine N-oxide (TMAO). A reduction in TMA formation has …

Summary Trimethylamine (TMA) N-oxide (TMAO), a gut-microbiota-dependent metabolite,
both enhances atherosclerosis in animal models and is associated with cardiovascular risks …

Abstract Background: Trimethylamine-N-oxide (TMAO) is formed in the liver from
trimethylamine (TMA), a product exclusively generated by the gut microbiota from dietary …

Morbidity and mortality of cardiovascular diseases (CVDs) are exceedingly high worldwide.
Researchers have found that the occurrence and development of CVDs are closely related …

Trimethylamine (TMA) is a gut microbiota-derived metabolite which comes from diets rich of
choline, betaine or l-carnitine and could be further converted to Trimethylamine-N-oxide …

Trimethylamine N-oxide (TMAO) is a biologically active molecule and is a putative promoter
of chronic diseases including atherosclerosis in humans. Host intestinal bacteria produce its …

In recent years, a number of studies have alluded to the importance of the intestinal
microflora in controlling whole-body metabolic homeostasis and organ physiology. In …

Purpose Plasma trimethylamine-N-oxide (TMAO) levels have been shown to correlate with
increased risk of metabolic diseases including cardiovascular diseases. TMAO exposure …