Towards an Understanding of the Growing Incidence of Colorectal Cancer and Appendiceal Neoplasms in Young Adults

RR Mikaeel - 2022 - digital.library.adelaide.edu.au
Colorectal cancer (CRC) incidence and mortality rates are rising in young adults aged< 50
years old [referred to as young-onset CRC (YOCRC)] in Australia and many other countries …

[HTML][HTML] Trends in the epidemiology of young-onset colorectal cancer: a worldwide systematic review

K Saad El Din, JM Loree, EC Sayre, S Gill, CJ Brown… - Bmc Cancer, 2020 - Springer
Background Recent data suggest that the risk of young-onset colorectal cancer (yCRC), in
adults less than 50 years of age, is increasing. To confirm findings and identify contemporary …

Young‐onset colorectal cancer is associated with a personal history of type 2 diabetes

RR Mikaeel, EL Symonds, J Kimber… - Asia‐Pacific Journal …, 2021 - Wiley Online Library
Background Colorectal cancer (CRC) is rising in incidence in young adults, and this
observation is currently unexplained. We investigated whether having a personal history of …

[HTML][HTML] Genome-wide association studies and Mendelian randomization analyses provide insights into the causes of early-onset colorectal cancer

RS Laskar, C Qu, JR Huyghe, T Harrison, RB Hayes… - Annals of …, 2024 - Elsevier
Background The incidence of early-onset colorectal cancer (EOCRC; diagnosed< 50 years
of age) is rising globally; however, the causes underlying this trend are largely unknown …

Global patterns and trends in colorectal cancer incidence in young adults

RL Siegel, LA Torre, I Soerjomataram, RB Hayes… - Gut, 2019 - gut.bmj.com
Objective Early-onset colorectal cancer (CRC) is increasing in the USA despite rapid
declines in older ages. Similar patterns are reported in Australia and Canada, but a …

Identifying genetic loci associated with an increased risk for early-onset colorectal cancer

D Kelsen, I Ben-Aharon, N Gordon - Annals of Oncology, 2024 - annalsofoncology.org
In this issue of the Annals of Oncology, Laskar and colleagues report the results of a meta
analysis of genome wide association data, with annotating demographic and lifestyle …

Association of endogenous and exogenous factors with early-onset colorectal cancer: germline mutations, epigenetic modifications, diet and lifestyle habits

M Puzzono - 2024 - usiena-air.unisi.it
The incidence of early-onset colorectal cancer (eoCRC), defined as colorectal cancer
occurring in young adults under the age of 50, is increasing globally. However, knowledge …

The incidence of young-onset colorectal cancer in Canada continues to increase

DE O'Sullivan, RJ Hilsden, Y Ruan, N Forbes… - Cancer …, 2020 - Elsevier
Background Despite decreases in the overall incidence of colorectal cancer (CRC) in
Canada, a concerning increase has been observed among younger adults in recent years …

[HTML][HTML] Young-Onset Colorectal Cancer: Current State of Knowledge and Future Perspectives

M Ozer, K Ng - gmka.org
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related mortality worldwide [1]. The incidence of CRC varies across geographical …

[HTML][HTML] Early-age-onset colorectal cancer in Canada: Evidence, issues and calls to action

MA De Vera, S Gill, S Ashamalla, D Schiller… - 2022 - mdpi.com
The inaugural Early-Age-Onset Colorectal Cancer Symposium was convened in June 2021
to discuss the implications of rapidly rising rates of early-age-onset colorectal cancer (EAO …