Kidney disease is now recognized as a global health problem and is associated with
increased morbidity and mortality, along with high economic costs. To develop new …

Stem cells have enormous potential for developing novel therapies for kidney disease but
our current inability to direct their differentiation to specialised renal cells presents a barrier …

Human induced pluripotent stem cells (hiPSCs) offer great opportunities within the 3R
framework. In the field of toxicology, they may contribute greatly to the reduction and …

Background To overcome the limitations of current alternative therapies for chronic kidney
disease (CKD), tissue engineering-mediated regeneration strategies have demonstrated the …

The use of adult stem/progenitor cells is a challenge in current research about kidney
functional regeneration. In this framework, material‐induced stem cell differentiation can …

Extracellular matrix (ECM) coatings have been used to improve cell performance in
bioartificial kidneys (BAKs). However, their effects on primary human renal proximal tubule …

The treatment of renal injury by autologous, patient-specific adult stem cells is still an unmet
need. Unsolved issues remain the spatial integration of stem cells into damaged areas of the …

In regenerative medicine, stem/progenitor cells are emerging as potential candidates for the
treatment of renal failure. However, the mechanism of regeneration of renal tubules from …

To date, strategies aiming to modulate cell to extracellular matrix (ECM) interactions during
organoid derivation remain largely unexplored. Here renal decellularized ECM (dECM) …

Bioartificial kidneys (BAKs) containing human primary renal proximal tubule cells (HPTCs)
have been applied in clinical trials. The results were encouraging, but also showed that …