Arginine-Glycine-Aspartate (RGD)-recognizing cell surface integrins are involved in tumor
growth, invasiveness/metastases, and angiogenesis, and are therefore an attractive …

Integrin αvβ3, a subtype of the arginine-glycine-aspartate (RGD)–recognizing cell surface
integrins, is upregulated on endothelial cells during angiogenesis and on tumor cells …

Aim: To visualize neovasculature and/or tumour integrin α v β 3 we selected the binding
moiety Arg-Gly-Asp-D-Tyr-Lys (RGDyK) coupled to NODAGA for labeling with 68 Ga …

Purpose The integrin αvβ3 and aminopeptidase N (APN/CD13) play vital roles in the tumor
angiogenesis process. They are highly expressed in a variety of tumor cells and proliferating …

Introduction Multiple peptide receptors are co-expressed in many types of cancers. Arg-Gly-
Asp (RGD) and GE11 peptides specifically target integrin α V β 3 and EGFR, respectively …

Introduction The aim of this study was to synthesize and perform a side-by-side comparison
of two new tumor-angiogenesis PET tracers 68 Ga-NODAGA-E [c (RGDyK)] 2 and 64 Cu …

349 Objectives: This study aimed to explore the safety, biodistribution and dosimetry of a
long-acting integrin α v β 3-targeted PET tracer 64 Cu-NOTA-EB-RGD in humans, and to …

Abstract Purpose Radiolabeled cyclic RGD (Arg-Gly-Asp) peptides have great potential for
the early tumor detection and noninvasive monitoring of tumor metastasis and therapeutic …

1487 Objectives Tumor neovasculature compared to established vessels expresses different
integrins, in particular αvβ3 and αvβ5. The integrin-binding moiety Arg-Gly-Asp (RGD) was …

Integrin αvβ3 plays a critical role in tumor-induced angiogenesis and metastasis and has
become a promising diagnostic indicator and therapeutic target for various solid tumors …