The basic helix-loop-helix/leucine zipper (bHLH/ZIP) microphthalmia-associated
transcription factor (MITF) regulates transcription of genes encoding enzymes essential for …

Cells of the retinal pigment epithelium (RPE) play major roles in metabolic functions,
maintenance of photoreceptor function, and photoreceptor survival in the retina. They …

The microphthalmia gene (mi) appears to be required for pigment cell development, based
on its mutation in mi mice. The mi gene encodes a basic helix-loop-helix leucine zipper …

Purpose.: Myopia, or nearsightedness, is a common ocular genetic disease for which over
20 candidate genomic loci have been identified. The high-grade myopia locus, MYP3, has …

Microphthalmos is a rare congenital anomaly characterized by reduced eye size and visual
deficits of variable degree. Sporadic and hereditary microphthalmos have been associated …

Among more than 80 different loci related to mouse coat color, microphthalmia‐associated
transcription factor (Mitf) encoded at the mouse microphthalmia locus is one of the most …

The deafness–pigmentary disorder Waardenburg Syndrome Type 2 is caused by mutations
in the human Microphthalmia-associated transcription factor (MITF) gene. Multiple related …

Mitf (gene for microphthalmia‐associated transcription factor) encodes a transcription factor
of the basic/helix‐loop‐helix/leucine‐zipper family and is a key regulator during the …

Therapeutic inhibition of hypoxia-inducible factor-1alpha (HIF-1α) action has emerged as a
potential approach for managing several diseases, including myopia. Herein, we analyzed …

Myopia, or nearsightedness, is the most common eye disorder, resulting primarily from
excess elongation of the eye. The etiology of myopia, although known to be complex, is …