Cancer is a major cause of death worldwide despite significant advances in surgery and
biology. Several recent studies have suggested that there is a close connection between …

Cyclooxygenase-2 (Cox-2) is an inducible enzyme involved in the conversion of arachidonic
acid to prostaglandin and other eicosanoids. Molecular pathology studies have revealed …

Cyclooxygenase (COX) enzymes are pivotal in inflammation and cancer development. COX-
2, in particular, has been implicated in tumor growth, angiogenesis, and immune evasion …

Increased prostaglandin (PG) production is associated with many inflammatory
pathophysiological conditions; it is derived from arachidonic acid by either of two enzymes …

Cancer is a leading cause of death worldwide. The expression of COX-2 and prostaglandins
has not only been associated with various types of cancer but is also directly proportional to …

The recent marketing of two selective cyclooxygenase-2 (COX-2) inhibitors, celecoxib and
rofecoxib is remarkable considering that COX-2 was only discovered eight years ago as a …

Acute inflammation or resolved inflammation is an adaptive host defense mechanism and is
self-limiting, which returns the body to a state of homeostasis. However, unresolved …

Cyclooxygenase-2 (COX-2) is an enzyme induced by inflammatory and mitogenic stimuli
and results in enhanced synthesis of PGs in inflamed and neoplastic tissues. It is associated …

The biological role of COX-2, the inducible form of cyclooxygenase, is to convert arachidonic
acid into prostaglandins (PGs) and thromboxanes (TXs). Overexpressed in many tumors …

Prostaglandins and thromboxane are lipid signaling molecules deriving from arachidonic
acid by the action of the cyclooxygenase isoenzymes COX-1 and COX-2. The role of …