It is widely accepted that increasing adiposity is associated with insulin resistance and
increased risk of type 2 diabetes. The predominant paradigm used to explain this link is the …

BACKGROUND: It is widely accepted that increasing adiposity is associated with insulin
resistance and increased risk of type II diabetes. The predominant paradigm used to explain …

The primary genetic, environmental, and metabolic factors responsible for causing insulin
resistance and pancreatic β-cell failure and the precise sequence of events leading to the …

Recent studies underscore the need to better understand the mechanisms linking visceral
adiposity with liver fat accumulation, the mechanisms by which ectopic fat accumulation …

Approximately two-thirds of the US population are overweight, which means that insulin
resistance is probably the most common metabolic abnormality in the USA. I propose three …

Research of the past decade has increased our understanding of the role adipose tissue
plays in health and disease. Adipose tissue is now recognized as a highly active metabolic …

Background The diminished glucose lowering effect of insulin in obesity, called “insulin
resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious …

Obesity is associated with insulin resistance. Insulin resistance underlies a constellation of
adverse metabolic and physiological changes (the insulin resistance syndrome) which is a …

We present multiple findings on derangements in lipid metabolism in type 2 diabetes. The
increase in the intracellular deposition of triglycerides (TG) in muscles, liver and pancreas in …

Insulin inhibits systemic nonesterified fatty acid (NEFA) flux to a greater degree than glucose
or any other metabolite. This remarkable effect is mainly due to insulin-mediated inhibition of …