Individuals chronically infected with HIV-1 harbor complex viral populations within their
bloodstreams. Recently, it has come to light that when these people infect others, the new …

Most HIV-1 variants isolated from early-stage human infections do not use nonhuman
primate versions of the CD4 receptor for cellular entry, or they do so poorly. We and others …

Infection with human and simian immunodeficiency viruses (HIV/SIV) requires binding of the
viral envelope glycoprotein (Env) to the host protein CD4 on the surface of immune cells …

ABSTRACT HIV-1 replicates poorly in macaque cells, and this had hindered the
advancement of relevant nonhuman primate model systems for HIV-1 infection and …

HIV entry: are all receptors created equal? | Nature Immunology Skip to main content Thank
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Human and simian immunodeficiency viruses (HIV/SIVs) use CD4 as the primary receptor to
enter target cells. Here, we show that the chimpanzee CD4 is highly polymorphic, with nine …

All HIV and SIV strains can enter cells by binding to cell-surface CD4. Therapeutics
designed to intervene in viral entry by blocking HIV attachment to CD4, may not work if entry …

Pandemic HIV-1 (group M) emerged following the cross-species transmission of a simian
immunodeficiency virus from chimpanzees (SIVcpz) to humans. Primate lentiviruses …

CD4 is known to be an important receptor for human immunodeficiency virus type 1 (HIV-1)
infection of T lymphocytes and macrophages. However, the limiting steps in CD4-dependent …

HIV-1 naturally infects chimpanzees and humans, but does not infect Old World monkeys
because of replication blocks that occur after virus entry into the cell. To understand the …