The surface molecule CD4 plays a key role in initiating cellular entry by the human
immunodeficiency virus type 1 (HIV-1), and it is now recognized as acting synergistically …

The human immunodefiency virus (HIV) uses the human CD4 glycoprotein as a receptor for
infection of susceptible cells. Cells expressing a series of mutated forms of the CD4 gene …

HIV-1 use CD4 receptors to infect their primary targets, CD4+ cells, whereas CD8+ cells
have a protective role against HIV-1. We recently isolated HIV-1-producing CD8+ clones …

HIV-1 infection of nonhuman primates does not lead to the acquired immunodeficiency
syndrome seen in humans. The basis for this lack of disease progression in these animals is …

Immunogenic, broadly reactive epitopes of the HIV-1 envelope glycoprotein could serve as
important targets of the adaptive humoral immune response in natural infection and …

CD4 is a co-receptor for binding of T cells to antigen-presenting cells and the primary
receptor for the human immunodeficiency virus type 1 (HIV). CD4 exists in three different …

Background: Many details of HIV-1 molecular virology have been translated into lifesaving
antiviral drugs. Yet, we have an incomplete understanding of the cells in which HIV-1 …

To study the interaction between the primate lentiviruses simian immunodeficiency virus
(SIV) and human immunodeficiency virus (HIV) and the CD4 receptor we have cloned and …

Enveloped viruses penetrate host cells by two distinct. mechanisms: by direct fusion
between viral and cell membrane or by receptor-mediated endocytosis. Though not mutually …

CD4 is the primary receptor for human immunodeficiency virus (HIV). The binding site for the
surface glycoprotein of HIV type 1 (HIV-1), gp120, has been mapped to the C'-C" region of …