Rhesus macaques are used to model human immunodeficiency virus type 1 (HIV-1)
infections, but they are not natural hosts of HIV-1 or any simian immunodeficiency virus …

The CD4 binding site (CD4bs) on the HIV-1 envelope plays a major role in determining the
capacity of R5 viruses to infect primary macrophages. Thus, envelope determinants within or …

In the last three decades, extensive research on human immunodeficiency virus (HIV) has
highlighted its capability to exploit a variety of strategies to enter and infect immune cells …

The CD4 receptor, by stabilizing TCR-MHC II interactions, plays a central role in adaptive
immunity. It also serves as the HIV docking receptor. The HIV gp120 envelope protein binds …

HIV-1 exhibits a narrow host range, hindering the development of a robust animal model of
pathogenesis. Past studies have demonstrated that the restricted host range of HIV-1 may …

A division of labor: DC subsets and HIV receptor diversity | Nature Immunology Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

Dendritic cells (DC) play a pivotal role in transmission and dissemination of HIV-1. Earlier
studies reported that DC present at the site of infection trap virus particles via DC-SIGN and …

HIV-1 is the single most important sexually transmitted disease in humans from a global
health perspective. Among human lentiviruses, HIV-1 M group has uniquely achieved …

It is probably safe to say that at the beginning of 1996, most HIV scientists knew little about
chemokines and their receptors, whereas those who studied these molecules had little …

Sexual transmission of HIV-1 consists of processes that exert either positive or negative
selection pressure on the virus. The sum of these selection pressures lead to the …