Searching the antitumor drug targets among proteasomes,“ubiquitous” enzyme systems,
may provide a new impulse to the antitumor drug discovery. In this study, changes in the …

Purpose: The 20S proteasome is a multicatalytic protein complex, which plays a major role
in intracellular protein degradation. In mammalian cells, it consists of 28 subunits arranged …

The activity of the proteasome, a polyfunctional enzymatic complex, is known to undergo
changes during cancer development. This phenomenon is probably caused by the changes …

Activity of the proteasome, polyfunctional enzymatic complex, is known to undergo changes
during cancer development. This phenomenon is, probably, caused by the changes in …

Mammalian and human cells contain multiple forms of proteasomes different in their
structure and functions. 26S-proteasome pool regulates most cellular processes through …

Proteasomes are large multicatalytic proteinase complexes located in the cytosol and the
nucleus of eukaryotic cells. The ubiquitin-proteasome system is responsible for the …

Proteasomes are multisubunit proteases involved in many cellular processes, including
tumorigenesis and immune surveillance. In their catalytic core, the 20S proteasome, the β1 …

The proteasome is a proteolytic complex that constitutes the main pathway for degradation
of intracellular proteins in eukaryotic cells. It regulates many physiological processes and its …

The proteasome is a multicatalytic protease complex present in all eukaryotic cells, which
plays a critical role in regulating essential cellular processes. During the immune response …

The ubiquitin-proteasome system (UPS) is one of the major protein degradation pathways in
eukaryotic cells. Abnormal functioning of this system has been observed in cancer and …