Microbiota effects on carcinogenesis: initiation, promotion, and progression

LR Lopez, RM Bleich, JC Arthur - Annual review of medicine, 2021 - annualreviews.org
Carcinogenesis is a multistep process by which normal cells acquire genetic and epigenetic
changes that result in cancer. In combination with host genetic susceptibility and …

Microbiota and cancer: current understanding and mechanistic implications

AA Khan, AT Sirsat, H Singh, P Cash - Clinical and Translational Oncology, 2022 - Springer
During last few decades, role of microbiota and its importance in several diseases has been
a hot topic for research. The microbiota is considered as an accessory organ for maintaining …

Redrawing therapeutic boundaries: microbiota and cancer

J Sholl, GD Sepich-Poore, R Knight, T Pradeu - Trends in cancer, 2022 - cell.com
The unexpected roles of the microbiota in cancer challenge explanations of carcinogenesis
that focus on tumor-intrinsic properties. Most tumors contain bacteria and viruses, and the …

Cancer and the microbiota

WS Garrett - Science, 2015 - science.org
A host's microbiota may increase, diminish, or have no effect at all on cancer susceptibility.
Assigning causal roles in cancer to specific microbes and microbiotas, unraveling host …

Microbiota as a mediator of cancer progression and therapy

JL Pope, S Tomkovich, Y Yang, C Jobin - Translational Research, 2017 - Elsevier
Complex and intricate circuitries regulate cellular proliferation, survival, and growth, and
alterations of this network through genetic and epigenetic events result in aberrant cellular …

The role of the microbiome in cancer development and therapy

AP Bhatt, MR Redinbo… - CA: a cancer journal for …, 2017 - Wiley Online Library
Answer questions and earn CME/CNE The human body harbors enormous numbers of
microbiota that influence cancer susceptibility, in part through their prodigious metabolic …

Locoregional effects of microbiota in a preclinical model of colon carcinogenesis

S Tomkovich, Y Yang, K Winglee, J Gauthier… - Cancer research, 2017 - AACR
Inflammation and microbiota are critical components of intestinal tumorigenesis. To dissect
how the microbiota contributes to tumor distribution, we generated germ-free (GF) ApcMin/+ …

Microbiota, epithelium, inflammation, and TGF-β signaling: An intricate interaction in oncogenesis

X Pang, Y Tang, X Ren, Q Chen, Y Tang… - Frontiers in …, 2018 - frontiersin.org
Microbiota has been widely considered to play a critical role in human carcinogenesis.
Recent evidence demonstrated that microbiota, epithelial barrier and inflammation has …

Carcinogenesis and therapeutics: the microbiota perspective

MCB Tsilimigras, A Fodor, C Jobin - Nature microbiology, 2017 - nature.com
Cancer arises from the acquisition of multiple genetic and epigenetic changes in host cells
over the span of many years, promoting oncogenic traits and carcinogenesis. Most cancers …

Emerging roles of the microbiome in cancer

SJ Bultman - Carcinogenesis, 2014 - academic.oup.com
Gene–environment interactions underlie cancer susceptibility and progression. Yet, we still
have limited knowledge of which environmental factors are important and how they function …