Multiple sclerosis (MS), a neuroinflammatory disease that affects millions worldwide, is
widely thought to be autoimmune in etiology. Historically, research into MS pathogenesis …

A growing body of evidence suggests that autoreactive CD8 T cells contribute to the disease
process in multiple sclerosis (MS). Lymphocytes in MS plaques are biased toward the CD8 …

Autoreactive CD4+ T cells, which target antigens in central nervous system (CNS) myelin,
are widely believed to play a critical role in the pathogenesis of multiple sclerosis (MS) in …

Multiple sclerosis (MS) is the most common human demyelinating disease of the central
nervous system. It is universally accepted that the immune system plays a major role in the …

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) of putative autoimmune origin. Recent evidence indicates that MS …

The role of CD8+ T cells in multiple sclerosis (MS) and its animal models has been
enigmatic. Most studies of MS have focused on the role of CD4+ Th1 T cells and many …

Multiple sclerosis afflicts more than 1 million individuals worldwide and is widely considered
to be an autoimmune disease. Traditionally, CD4+ T helper cells have almost exclusively …

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system
characterized by focal demyelination patches associated with inflammatory infiltrates …

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system
leading to demyelination and axonal/neuronal loss. Cumulating evidence points to a key …

T lymphocytes play a central role in the pathogenesis of multiple sclerosis (MS)(Zhang et al.,
1992). Both CD4+ and CD8+ T cells have been demonstrated in MS lesions, with CD4+ T …