Zoledronic acid (ZLD) is a bisphosphonate drug widely administered against pathological
conditions such as hypercalcemia of malignancy, osteoporosis, bone metastases from solid …

Zoledronic acid, a nitrogen‐containing bisphosphonate drug, is used for the treatment of
osteoporosis, Paget's disease of bone, and tumor‐induced osteolysis. Zoledronic acid has …

Aims Zoledronic acid (ZA), a FDA approved drug has used widely in the treatment of bone
metastasis complications, has been linked to renal toxicity with unclear mechanism. The …

Background Ifosfamide (IFO) is an alkylating agent administered against different types of
malignancies. Several cases of renal injury and serum electrolytes disturbances have been …

ABSTRACT Introduction: Zoledronic acid (ZA), a bisphosphonate, increases the levels of
cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α), and reactive …

The aim of this study was to identify biomarkers of zoledronate-induced nephrotoxicity and to
further characterize the mechanisms underlying this process by analyzing urinary …

The clinical utility of non-steroidal anti-inflammatory drugs (NSAIDs) is limited by their
gastrointestinal and renal toxicities. Indomethacin (an NSAID commonly used in toxicity …

Lithium is abundantly administered against bipolar disorder. On the other hand, the lithium-
induced renal injury is a clinical complication which commonly reveals as drug-induced …

Acute kidney injury (AKI) is an emergency condition that requires restrictive and appropriate
clinical interventions. Identifying mechanisms of organ injury is a critical step in developing …

Mitochondrial abnormality has been shown in many kidney disease models. However, its
role in the pathogenesis of chronic kidney diseases (CKDs) is still uncertain. In present …