Mitochondrial abnormality has been shown in many kidney disease models. However, its
role in the pathogenesis of chronic kidney diseases (CKDs) is still uncertain. In present …

Nephrotoxicity is an important adverse effect of oxidative stress induced by hexavalent
chromium [Cr (VI)]. The effect of ellagic acid, a dietary polyphenolic compound with potent …

Ifosfamide (IFO) kidney damage is an important organ toxicity in children and adults
undergoing chemotherapy. Previous evidence has shown that IFO toxic metabolites such as …

Object Doxorubicin (DOX) is an anthracycline drug used for cancer treatment. However, its
treatment is contiguous with renal toxic effects. This study aims to investigate the therapeutic …

Colistin (COL) belongs to the polymixin class of antibiotics used as the last line antibiotic
against drug-resistant infections. However, nephrotoxicity is the major deleterious and dose …

Background Cadmium is a well known environmental pollutant and strong toxic heavy metal,
that causes oxidative damage to various organs of the body, including the kidney. Cadmium …

Diabetic nephropathy (DN) has become the main cause of end-stage renal disease
worldwide, but the efficacy of current therapeutic strategies on DN remains unsatisfactory …

Methotrexate is a folate analog used against a wide range of diseases including
malignancies and autoimmune disorders. On the other hand, clinical use of the MTX is …

Cisplatin (CP) is a platinum compound of the alkylating agent class that is used for the
treatment of various types of cancer. However, CP treatments in cancer patients are …

The current study was prepared to assess the underlying mechanism of diclofenac (Diclo)-
stimulated renal oxidative damage (50 mg/kg/day for two consecutive days IP) and …