Glycerol injection in rats can lead to rhabdomyolysis, with the release of the intracellular
muscle content to the extracellular compartment and acute kidney injury (AKI). Oxidative …

Ethnopharmacological relevance Renal interstitial fibrosis (RIF) is a main pathological
process in chronic kidney disease (CKD). Demethylzeylasteral (DML), a major component of …

Aims Nephrotoxicity is one of the most serious health consequences of cadmium (Cd) toxic
exposure. Cd was associated with nephrotoxicity through different mechanisms including …

Background Reactive oxygen species (ROS) and inflammation both contribute to the
progression of aldosterone-induced renal injury. To better understand the underlying …

Background Oxidative stress and inflammatory responses are critical factors in calcium
oxalate (CaOx) crystal-induced renal injury. Reactive oxygen species (ROS) are usually …

Aims Aging and drug-induced side effects may contribute to deteriorate mitochondrial
bioenergetics in many tissues, including kidney and liver. One possibility is that the …

Environmental and occupational exposure to chromium compounds has become potential
aetiologic agent for kidney disease with excessive generation of free radicals, apoptosis …

Objective: In the present study, the protective effect of Roflumilast (ROF, a selective
phosphodiesterase (PDE-4) inhibitor) was investigated against cadmium (Cd)-induced …

This study was performed to examine whether clindamycin could protect against doxorubicin
(DOX)-induced acute nephrotoxicity, and if so, what molecular mechanisms responsible for …

Background Methotrexate (MTX) is a commonly used chemotherapy drug with known
nephrotoxic effects, including the potential for acute kidney injury. However, the precise …