Biological and clinical implications of early-onset cancers: a unique subtype

TC He, JA Li, ZH Xu, QD Chen, HL Yin, N Pu… - Critical Reviews in …, 2023 - Elsevier
In recent years, the incidence of cancers is continuously increasing in young adults. Early-
onset cancer (EOC) is usually defined as patients with cancers under the age of 50, and may …

Adolescent and young adult cancer biology

JV Tricoli, A Bleyer - The Cancer Journal, 2018 - journals.lww.com
Adolescent and young adult (AYA) patients with cancer have not attained the same
improvements in overall survival as either younger children or older adults. One possible …

The distinctive biology of cancer in adolescents and young adults

A Bleyer, R Barr, B Hayes-Lattin, D Thomas… - Nature Reviews …, 2008 - nature.com
One explanation for the relative lack of progress in treating cancer in adolescents and young
adults is that the biology of malignant diseases in this age group is different than in younger …

Is early-onset cancer an emerging global epidemic? Current evidence and future implications

T Ugai, N Sasamoto, HY Lee, M Ando… - Nature Reviews …, 2022 - nature.com
Over the past several decades, the incidence of early-onset cancers, often defined as
cancers diagnosed in adults< 50 years of age, in the breast, colorectum, endometrium …

Young-onset carcinogenesis–the potential impact of perinatal and early life metabolic influences on the epigenome

SG Barreto, SJ Pandol - Frontiers in Oncology, 2021 - frontiersin.org
The last decade has witnessed a significant rise in cancers in young adults. This spectrum of
solid organ cancers occurring in individuals under the age of 40 years (some reports …

Early‐onset colorectal cancer in young individuals

G Mauri, A Sartore‐Bianchi, AG Russo… - Molecular …, 2019 - Wiley Online Library
Treatment of young adults with colorectal cancer (CRC) represents an unmet clinical need,
especially as diagnosis in this population might lead to the greatest loss of years of life …

Young-onset cancers—early steps in the right direction

SG Barreto, I Ben-Aharon - Cancers, 2023 - mdpi.com
The global incidence of young-onset (YO) cancer is on the rise. Determining the cause of
this disturbing trend has been listed as one of the Grand Cancer Challenges [1]. The …

The biology of AYA cancers

JV Tricoli, A Bleyer, J Anninga, R Barr - Cancer in Adolescents and Young …, 2017 - Springer
Investigating the potential biological basis of age-related differences in outcome for AYA
with cancer could lead to a better understanding of the biology, facilitate the development of …

[HTML][HTML] Bimodal age distribution in cancer incidence

S Desai, AK Guddati - World Journal of Oncology, 2022 - ncbi.nlm.nih.gov
Cancer is caused by accumulation of genetic changes which include activation of
protooncogenes and loss of tumor suppressor genes. The age-specific incidence of cancer …

Biologic and clinical characteristics of adolescent and young adult cancers: acute lymphoblastic leukemia, colorectal cancer, breast cancer, melanoma, and sarcoma

JV Tricoli, DG Blair, CK Anders, WA Bleyer… - Cancer, 2016 - Wiley Online Library
Adolescent and young adult (AYA) patients with cancer have not attained the same
improvements in overall survival as either younger children or older adults. One possible …