Maternal interleukin-6 is associated with macaque offspring amygdala development and behavior

JSB Ramirez, AM Graham, JR Thompson… - Cerebral …, 2020 - academic.oup.com
Human and animal cross-sectional studies have shown that maternal levels of the
inflammatory cytokine interleukin-6 (IL-6) may compromise brain phenotypes assessed at …

Maternal interleukin-6 hampers hippocampal neurogenesis in adult rat offspring in a sex-dependent manner

A Mouihate, S Kalakh - Developmental Neuroscience, 2021 - karger.com
Maternal immune activation (MIA) during pregnancy leads to long-lasting effects on brain
development and function. Several lines of evidence suggest that the maternal inflammatory …

Maternal systemic interleukin-6 during pregnancy is associated with newborn amygdala phenotypes and subsequent behavior at 2 years of age

AM Graham, JM Rasmussen, MD Rudolph, CM Heim… - Biological …, 2018 - Elsevier
Background Maternal inflammation during pregnancy increases the risk for offspring
psychiatric disorders and other adverse long-term health outcomes. The influence of …

Maternal IL-6 during pregnancy can be estimated from newborn brain connectivity and predicts future working memory in offspring

MD Rudolph, AM Graham, E Feczko… - Nature …, 2018 - nature.com
Several lines of evidence support the link between maternal inflammation during pregnancy
and increased likelihood of neurodevelopmental and psychiatric disorders in offspring. This …

Maternal Interleukin-6 concentration during pregnancy is associated with variation in frontolimbic white matter and cognitive development in early life

JM Rasmussen, AM Graham, S Entringer, JH Gilmore… - Neuroimage, 2019 - Elsevier
Maternal inflammation during pregnancy can alter the trajectory of fetal brain development
and increase risk for offspring psychiatric disorders. However, the majority of relevant …

Alterations in behavior in adult offspring mice following maternal inflammation during pregnancy

G Hava, L Vered, M Yael, H Mordechai… - … : The Journal of the …, 2006 - Wiley Online Library
Maternal intrauterine inflammation during pregnancy poses a major threat of
neurodevelopmental brain damage in offspring and may cause poor cognitive and …

The placental interleukin-6 signaling controls fetal brain development and behavior

WL Wu, EY Hsiao, Z Yan, SK Mazmanian… - Brain, behavior, and …, 2017 - Elsevier
Epidemiological studies show that maternal immune activation (MIA) during pregnancy is a
risk factor for autism. However, mechanisms for how MIA affects brain development and …

Modestly increasing systemic interleukin-6 perinatally disturbs secondary germinal zone neurogenesis and gliogenesis and produces sociability deficits

FJ Velloso, A Wadhwa, E Kumari, I Carcea… - Brain, behavior, and …, 2022 - Elsevier
Epidemiologic studies have demonstrated that infections during pregnancy increase the risk
of offspring developing Schizophrenia, Autism, Depression and Bipolar Disorder and have …

Prenatal manipulations reduce the proinflammatory response to a cytokine challenge in juvenile monkeys

TM Reyes, CL Coe - Brain research, 1997 - Elsevier
Two studies were conducted to assess the potential long-term effects of prenatal stress on
the cytokine-related inflammatory response in juvenile rhesus monkeys. Subjects were …

[PDF][PDF] Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring

F Mirabella, G Desiato, S Mancinelli, G Fossati… - Immunity, 2021 - cell.com
Early prenatal inflammatory conditions are thought to be a risk factor for different
neurodevelopmental disorders. Maternal interleukin-6 (IL-6) elevation during pregnancy …