A guide to preclinical models of zoster-associated pain and postherpetic neuralgia

BE Warner, WF Goins, PR Kramer… - Varicella-zoster Virus …, 2021 - Springer
Reactivation of latent varicella-zoster virus (VZV) causes herpes zoster (HZ), which is
commonly accompanied by acute pain and pruritus over the time course of a zosteriform …

Varicella zoster virus-induced pain and post-herpetic neuralgia in the human host and in rodent animal models

PR Kinchington, WF Goins - Journal of neurovirology, 2011 - Springer
Pain and post-herpetic neuralgia (PHN) are common and highly distressing complications of
herpes zoster that remain a significant public health concern and in need of improved …

Further characterization of a rat model of varicella zoster virus–associated pain: Relationship between mechanical hypersensitivity and anxiety-related behavior, and …

FS Hasnie, J Breuer, S Parker, V Wallace, J Blackbeard… - Neuroscience, 2007 - Elsevier
Persistent herpes zoster-associated pain is a significant clinical problem and an area of
largely unmet therapeutic need. Progress in elucidating the underlying pathophysiology of …

Varicella-zoster virus early infection but not complete replication is required for the induction of chronic hypersensitivity in rat models of postherpetic neuralgia

BE Warner, MB Yee, M Zhang, RS Hornung… - PLoS …, 2021 - journals.plos.org
Herpes zoster, the result of varicella-zoster virus (VZV) reactivation, is frequently
complicated by difficult-to-treat chronic pain states termed postherpetic neuralgia (PHN) …

Allodynia in rats infected with varicella zoster virus—a small animal model for post-herpetic neuralgia

RG Dalziel, S Bingham, D Sutton, D Grant… - Brain research …, 2004 - Elsevier
The most common complication of herpes zoster is post-herpetic neuralgia (PHN), which
has been defined as severe pain occurring 1 month after rash onset or persisting for greater …

[HTML][HTML] Neuronal changes induced by Varicella Zoster Virus in a rat model of postherpetic neuralgia

JMG Guedon, MB Yee, M Zhang, SAK Harvey… - Virology, 2015 - Elsevier
A significant fraction of patients with herpes zoster, caused by Varicella Zoster Virus (VZV),
experience chronic pain termed postherpetic neuralgia (PHN). VZV-inoculated rats develop …

Recent advances in reducing the burden of herpes zoster and postherpetic neuralgia

RH Dworkin - The Journal of Pain, 2008 - jpain.org
After a primary varicella (chicken pox) in-fection, the varicella-zoster virus (VZV) establishes
latency in sensory ganglia throughout the nervous system. Herpes zoster (“shingles”) is …

Characterization of the host immune response in human ganglia after herpes zoster

K Gowrishankar, M Steain, AL Cunningham… - Journal of …, 2010 - Am Soc Microbiol
Varicella-zoster virus (VZV) causes varicella (chicken pox) and establishes latency in
ganglia, from where it reactivates to cause herpes zoster (shingles), which is often followed …

Zoster-associated pain and neural dysfunction

MC Rowbotham, KL Petersen - Pain, 2001 - journals.lww.com
The varicella zoster virus (VZV) is the smallest of the double-stranded DNA herpes viruses,
and the only one capable of producing two different diseases, varicella (chickenpox) and …

[HTML][HTML] Rodent models of postherpetic neuralgia: How far have we reached?

M Ou, J Chen, S Yang, L Xiao, D Xiong… - Frontiers in …, 2023 - frontiersin.org
Background Induced by varicella zoster virus (VZV), postherpetic neuralgia (PHN) is one of
the common complications of herpes zoster (HZ) with refractory pain. Animal models play …