Cardiac effects of acute hyperinsulinemia and chronic fat feeding

SM Tadinada - 2019 - search.proquest.com
Diabetic cardiomyopathy characterized by left ventricular hypertrophy predisposes diabetic
and obese individuals to development of cardiac dysfunction and subsequently to heart …

[HTML][HTML] High fat feeding in mice is insufficient to induce cardiac dysfunction and does not exacerbate heart failure

RE Brainard, LJ Watson, AM DeMartino, KR Brittian… - PloS one, 2013 - journals.plos.org
Preclinical studies of animals with risk factors, and how those risk factors contribute to the
development of cardiovascular disease and cardiac dysfunction, are clearly needed. One …

[HTML][HTML] Obesity-induced cardiac lipid accumulation in adult mice is modulated by G protein-coupled receptor kinase 2 levels

E Lucas, R Vila-Bedmar, AC Arcones… - Cardiovascular …, 2016 - Springer
Background The leading cause of death among the obese population is heart failure and
stroke prompted by structural and functional changes in the heart. The molecular …

Functional resilience of C57BL/6J mouse heart to dietary fat overload

SM Tadinada, ET Weatherford… - American Journal …, 2021 - journals.physiology.org
Molecular mechanisms underlying cardiac dysfunction and subsequent heart failure in
diabetic cardiomyopathy are incompletely understood. Initially we intended to test the role of …

[PDF][PDF] Linking cardaic insulin resistance and heart failure: GRK2 as an integrative node

E Lucas, M Jurado-Pueyo, R Vila-Bedmar, J Díez… - Cardiovasc Regen …, 2015 - Citeseer
G protein-coupled receptor kinase 2 (GRK2) has arisen as a signaling hub with critical
regulatory roles in cardiac function and dysfunction. Cardiac GRK2 levels are elevated …

High-fat diet feeding in mice may partially protect the heart from pressure overload induced heart failure-a longitudinal study of cardiac metabolism and function

E Manders, D Abdurrachim, M Nabben, K Nicolay… - archive.ismrm.org
Obesity increases the risk of heart failure, but obese heart failure patients have a better
prognosis and survival. Altered cardiac energy metabolism is proposed to be an important …

Effects of a high saturated fat diet on cardiac hypertrophy and dysfunction in response to pressure overload

DJ Chess, B Lei, BD Hoit, AM Azimzadeh… - Journal of cardiac …, 2008 - Elsevier
BACKGROUND: Dietary lipid content effects activation of peroxisome proliferator-activated
receptor-α (PPAR-α) and may accelerate cardiac hypertrophy and dysfunction in response …

[HTML][HTML] Downregulation of G protein-coupled receptor kinase 2 levels enhances cardiac insulin sensitivity and switches on cardioprotective gene expression patterns

E Lucas, M Jurado-Pueyo, MA Fortuño… - … et Biophysica Acta (BBA …, 2014 - Elsevier
G protein-coupled receptor kinase 2 (GRK2) has recently emerged as a negative modulator
of insulin signaling. GRK2 downregulation improves insulin sensitivity and prevents …

Hypertension, cardiac hypertrophy, and neurohumoral activity in a new animal model of obesity

JF Carroll, TM Dwyer, AW Grady… - American Journal …, 1996 - journals.physiology.org
Although obesity is a major risk factor for morbidity and mortality, the mechanisms mediating
cardiovascular abnormalities in response to weight gain are unclear. One reason for the …

Western diet impairs metabolic remodelling and contractile efficiency in cardiac hypertrophy

A Akki, AML Seymour - Cardiovascular research, 2009 - academic.oup.com
Aims Metabolic remodelling in cardiac hypertrophy is underscored by a reduction in fatty
acid (FA) oxidation. We tested whether this decline in FA oxidation in the presence of …