Diabetic cardiomyopathy characterized by left ventricular hypertrophy predisposes diabetic
and obese individuals to development of cardiac dysfunction and subsequently to heart …

Preclinical studies of animals with risk factors, and how those risk factors contribute to the
development of cardiovascular disease and cardiac dysfunction, are clearly needed. One …

Background The leading cause of death among the obese population is heart failure and
stroke prompted by structural and functional changes in the heart. The molecular …

Molecular mechanisms underlying cardiac dysfunction and subsequent heart failure in
diabetic cardiomyopathy are incompletely understood. Initially we intended to test the role of …

G protein-coupled receptor kinase 2 (GRK2) has arisen as a signaling hub with critical
regulatory roles in cardiac function and dysfunction. Cardiac GRK2 levels are elevated …

Obesity increases the risk of heart failure, but obese heart failure patients have a better
prognosis and survival. Altered cardiac energy metabolism is proposed to be an important …

BACKGROUND: Dietary lipid content effects activation of peroxisome proliferator-activated
receptor-α (PPAR-α) and may accelerate cardiac hypertrophy and dysfunction in response …

G protein-coupled receptor kinase 2 (GRK2) has recently emerged as a negative modulator
of insulin signaling. GRK2 downregulation improves insulin sensitivity and prevents …

Although obesity is a major risk factor for morbidity and mortality, the mechanisms mediating
cardiovascular abnormalities in response to weight gain are unclear. One reason for the …

Aims Metabolic remodelling in cardiac hypertrophy is underscored by a reduction in fatty
acid (FA) oxidation. We tested whether this decline in FA oxidation in the presence of …