MYC is a pleiotropic transcription factor involved in multiple cellular processes. While its
mechanism of action and targets are not completely elucidated, it has a fundamental role in …

Cancer comprises a heterogeneous disease, characterized by diverse features such as
constitutive expression of oncogenes and/or downregulation of tumor suppressor genes …

The oncogene Myc is deregulated in the majority of human tumors and drives numerous
hallmarks of cancer. Despite its indisputable role in cancer development and maintenance …

Summary c-MYC controls global gene expression and regulates cell proliferation, cell
differentiation, cell cycle, metabolism and apoptosis. According to some estimates, MYC is …

Abstract MYC proteins (c-MYC, MYCN, and MYCL) regulate processes involved in many if
not all aspects of cell fate. Therefore, it is not surprising that the MYC genes are deregulated …

The transcription factor proto-oncogene c-MYC (hereafter MYC) was first identified more
than 3 decades ago and has since been found deregulated in a wide variety of the most …

MYC, a key member of the Myc-proto-oncogene family, is a universal transcription amplifier
that regulates almost every physiological process in a cell including cell cycle, proliferation …

The basic helix–loop–helix protein Myc is a renowned transcription factor controlling
disparate aspects of cell physiology that, together, allow efficient proliferation of somatic …

MYC regulates a complex biological program by transcriptionally activating and repressing
its numerous target genes. As such, MYC is a master regulator of many processes, including …

MYC can be considered to be one of the most pressing and important targets for the
development of novel anti-cancer therapies. This is due to its frequent dysregulation in …