The influence of parasite genetic factors on immune responses and development of severe
pathology of malaria is largely unknown. In this study, we performed genome-wide …

The pathogenesis of infectious diseases depends on the interaction of host and pathogen. In
Plasmodium falciparum malaria, host and parasite processes can be assessed by dual RNA …

Background The liver is responsible for a range of functions in vertebrates, such as
metabolism and immunity. In malaria, the liver plays a crucial role in the interaction between …

Recent initiatives to improve translation of findings from animal models to human disease
have focussed on reproducibility but quantifying the relevance of animal models remains a …

Malaria has a complex pathology with varying manifestations and symptoms, effects on host
tissues, and different degrees of severity and ultimate outcome, depending on the causative …

High-density oligonucleotide microarrays are widely used to study gene expression in cells
exposed to a variety of pathogens. This study addressed the global genome-wide …

Plasmodium falciparum malaria drives immunoregulatory responses across multiple cell
subsets, which protects from immunopathogenesis, but also hampers the development of …

Background Plasmodium sporozoites migrate to the liver where they traverse several
hepatocytes before invading the one inside which they will develop and multiply into …

Background The development and outcome of cerebral malaria (CM) reflects a complex
interplay between parasite-expressed virulence factors and host response to infection. The …

Malaria infection triggers vigorous host immune responses; however, the parasite ligands,
host receptors, and the signaling pathways responsible for these reactions remain unknown …