The blood transcriptome of malaria patients has been used extensively to elucidate the
pathophysiological mechanisms and host immune responses to disease, identify candidate …

Plasmodium falciparum is the main causative agent of human malaria. During the
intraerythrocytic development cycle, the P. falciparum morphology changes dramatically …

While the liver and blood stages of the Plasmodium life cycle are commonly regarded as two
separate fields of malaria research, several studies have pointed towards the existence of a …

Malaria remains a major infectious disease that affects millions of people. Once infected with
Plasmodium parasites, a host can develop a broad range of clinical presentations, which …

Immunity that controls parasitemia and inflammation during Plasmodium falciparum (Pf)
malaria can be acquired with repeated infections. A limited understanding of this complex …

Background Malaria is a one of the most important infectious diseases and is caused by
parasitic protozoa of the genus Plasmodium. Previously, quantitative characterization of the …

Identifying the genetic determinants of phenotypes that impact disease severity is of
fundamental importance for the design of new interventions against malaria. Here we …

Malaria parasites follow a complex life cycle that consists of multiple stages that span from
the human host to the mosquito vector. Among the species causing malaria, Plasmodium …

To understand the molecular mechanisms of parasitism in vivo, it is essential to elucidate
how the transcriptomes of the human hosts and the infecting parasites affect one another …

Within the human host, the malaria parasite Plasmodium falciparum is exposed to multiple
selection pressures. The host environment changes dramatically in severe malaria, but the …