MYC is one of the most important oncogenes and is overexpressed in the majority of
cancers. G-Quadruplexes are noncanonical four-stranded DNA secondary structures that …

Conspectus DNA G-quadruplex secondary structures formed in guanine-rich human
telomeres and oncogene promoters are functionally important and have emerged as a …

The formation of G‐quadruplex structures can regulate telomerase activity and the
expression of oncogenes at the transcriptional and translational levels. Therefore …

Guanine-rich DNA sequences have the propensity to adopt four-stranded tetrahelical G-
quadruplex (G4) structures that are overrepresented in gene promoters. The structural …

Transcriptional control of c-myc oncogene is an important strategy for antitumor drug design.
G-quadruplexes in the promoter region have been proven to be the transcriptional down …

This G-rich region of the c-MYC promoter has been shown to form a G-quadruplex structure
that acts as a silencer element for c-MYC transcriptional control. In the present work, we …

The discovery that certain indenoisoquinolines inhibit the religation reaction of DNA in the
topoisomerase I-DNA-indenoisoquinoline ternary complex led to a structure-based drug …

Unimolecular parallel-stranded G-quadruplex structures are found to be prevalent in gene
promoters. The nuclease hypersensitivity element III1 (NHE III1) of the c-MYC promoter can …

Herein, we demonstrate the design, synthesis, biophysical properties, and preliminary
biological evaluation of 6-substituted indenoisoquinolines as a new class of G-quadruplex …

ABL. 2, 3 C-myc is an important proto-oncogene, which is linked to potentiation of cellular
proliferation and to inhibition of differentiation and acts as both a transcriptional activator and …