[HTML][HTML] Bispecific T cell engagers and their synergistic tumor immunotherapy with oncolytic viruses
Q Huang, WQ Cai, ZW Han, MY Wang… - American Journal of …, 2021 - ncbi.nlm.nih.gov
Tumor immunotherapy, especially T cell based therapy, is becoming the main force in
clinical tumor therapies. Bispecific T cell engager (BiTE) uses the single chain variable …
clinical tumor therapies. Bispecific T cell engager (BiTE) uses the single chain variable …
Oncolytic viruses encoding bispecific T cell engagers: a blueprint for emerging immunovirotherapies
JPW Heidbuechel, CE Engeland - Journal of hematology & oncology, 2021 - Springer
Bispecific T cell engagers (BiTEs) are an innovative class of immunotherapeutics that
redirect T cells to tumor surface antigens. While efficacious against certain hematological …
redirect T cells to tumor surface antigens. While efficacious against certain hematological …
Bi-and tri-specific T cell engager-armed oncolytic viruses: next-generation cancer immunotherapy
Oncolytic viruses (OVs) are potent anti-cancer biologics with a bright future, having
substantial evidence of efficacy in patients with cancer. Bi-and tri-specific antibodies …
substantial evidence of efficacy in patients with cancer. Bi-and tri-specific antibodies …
Bispecific T‐cell engagers for cancer immunotherapy
AM Huehls, TA Coupet… - Immunology and cell …, 2015 - Wiley Online Library
Bispecific T‐cell engagers (BiTEs) are a new class of immunotherapeutic molecules
intended for the treatment of cancer. These molecules enhance the patient's immune …
intended for the treatment of cancer. These molecules enhance the patient's immune …
The BiTE (bispecific T‐cell engager) platform: development and future potential of a targeted immuno‐oncology therapy across tumor types
H Einsele, H Borghaei, RZ Orlowski, M Subklewe… - Cancer, 2020 - Wiley Online Library
Immuno‐oncology therapies engage the immune system to treat cancer. BiTE (bispecific T‐
cell engager) technology is a targeted immuno‐oncology platform that connects patients' …
cell engager) technology is a targeted immuno‐oncology platform that connects patients' …
Solid tumor immunotherapy with T cell engager‐armed oncolytic viruses
EM Scott, MR Duffy, JD Freedman… - Macromolecular …, 2018 - Wiley Online Library
Oncolytic viruses (OVs) are novel anticancer agents that combine direct cancer cell killing
with the stimulation of antitumor immunity. In addition, OVs can be engineered to deliver …
with the stimulation of antitumor immunity. In addition, OVs can be engineered to deliver …
Therapeutic bispecific T-cell engager antibody targeting the transferrin receptor
M Fu, Q He, Z Guo, X Zhou, H Li, L Zhao… - Frontiers in …, 2019 - frontiersin.org
Bispecific T-cell engager antibodies (BiTE) have been explored as a means to recruit
cytolytic T cells to kill tumor cells. The transferrin receptor (TfR) is highly expressed on the …
cytolytic T cells to kill tumor cells. The transferrin receptor (TfR) is highly expressed on the …
Nanobody-based bispecific T-cell engager (Nb-BiTE): a new platform for enhanced T-cell immunotherapy
X Yang, X Lin, W Shi, S Xie, X Huang, S Yin… - … and Targeted Therapy, 2023 - nature.com
A novel bispecific T-cell engager (BiTE) has been developed as an efficient
immunotherapeutic molecule specifically bringing the T-cell and the tumor target together for …
immunotherapeutic molecule specifically bringing the T-cell and the tumor target together for …
Bispecific T-cell engaging antibodies for cancer therapy
PA Baeuerle, C Reinhardt - Cancer research, 2009 - AACR
There is increasing evidence that T cells are able to control tumor growth and survival in
cancer patients, both in early and late stages of the disease. However, tumor-specific T-cell …
cancer patients, both in early and late stages of the disease. However, tumor-specific T-cell …
T Cell bispecific antibodies: an antibody-based delivery system for inducing antitumor immunity
D Kamakura, R Asano, M Yasunaga - Pharmaceuticals, 2021 - mdpi.com
As a breakthrough immunotherapy, T cell bispecific antibodies (T-BsAbs) are a promising
antibody therapy for various kinds of cancer. In general, T-BsAbs have dual-binding …
antibody therapy for various kinds of cancer. In general, T-BsAbs have dual-binding …