Multimodal analysis of the effects of dexamethasone on high-altitude cerebral oedema: protocol for a pilot study

O Fisher, RA Benson, S Wayte, PK Kimani… - Trials, 2019 - Springer
Background Acute mountain sickness (AMS) is a cluster of symptoms that commonly occur
in those ascending to high altitudes. Symptoms can include headaches, nausea, insomnia …

Dexamethasone for prophylaxis and treatment of acute mountain sickness

MB Rabold - Journal of Wilderness Medicine, 1992 - Elsevier
Acute mountain sickness (AMS) is a syndrome induced by hypobaric hypoxia in individuals
who ascend rapidly to altitudes above 2500 m and may represent an early form of high …

MRI evidence: acute mountain sickness is not associated with cerebral edema formation during simulated high altitude

K Mairer, M Göbel, M Defrancesco, M Wille, H Messner… - PloS one, 2012 - journals.plos.org
Acute mountain sickness (AMS) is a common condition among non-acclimatized individuals
ascending to high altitude. However, the underlying mechanisms causing the symptoms of …

Acute mountain sickness and high altitude cerebral edema: a review for the practitioner

PH Hackett - Health & Height. V World Congress on Mountain …, 2003 - books.google.com
Hypoxia affects all organ systems, but primarily the brain. On ascent to high altitude,
hypoxemia triggers time-dependent processes causing acute mountain sickness (AMS), a …

Acute mountain sickness: controversies and advances

P Bartsch, DM Bailey, MM Berger, M Knauth… - … altitude medicine & …, 2004 - liebertpub.com
This review discusses the impact of recent publications on pathophysiologic concepts and
on practical aspects of acute mountain sickness (AMS). Magnetic resonance imaging …

No evidence of cerebral oedema in severe acute mountain sickness

R Fischer, C Vollmar, M Thiere, C Born, M Leitl… - …, 2004 - journals.sagepub.com
In a randomized, double-blind cross-over study 10 subjects were exposed to a simulated
altitude of 4500 m for 10 h after administration of placebo, acetozolamide (250 mg bid) or …

Cognitive effects of dexamethasone at high altitude

J Lafleur, M Giron, M Demarco… - Wilderness & …, 2003 - journals.sagepub.com
Objective The major therapeutic effect of dexamethasone on persons affected by high-
altitude illness may be upon vascular leakiness with a consequent decrease in cerebral …

What role does the blood brain barrier play in acute mountain sickness?

A Baneke - Travel medicine and infectious disease, 2010 - Elsevier
As high altitude travel increases, acute mountain sickness (AMS) and life threatening high
altitude cerebral oedema (HACE) are becoming more prevalent. Acute mountain sickness …

Systemic pro-inflammatory response facilitates the development of cerebral edema during short hypoxia

TT Song, YH Bi, YQ Gao, R Huang, K Hao, G Xu… - Journal of …, 2016 - Springer
Background High-altitude cerebral edema (HACE) is the severe type of acute mountain
sickness (AMS) and life threatening. A subclinical inflammation has been speculated, but the …

Early brain swelling in acute hypoxia

DJ Dubowitz, EAW Dyer… - Journal of Applied …, 2009 - journals.physiology.org
Acute mountain sickness (AMS) and high-altitude cerebral edema share common clinical
characteristics, suggesting cerebral swelling may be an important factor in the …