Historically, drug research targeted to pain treatment has focused on trying to prevent the
propagation of action potentials in the periphery from reaching the brain rather than …

Patients with inflammatory or neuropathic pain experience hypersensitivity to mechanical,
thermal and/or chemical stimuli. Given the diverse etiologies and molecular mechanisms of …

The vanilloid receptor TRPV1 is now recognized as a molecular integrator of painful stimuli
ranging from noxious heat to endovanilloids in inflammation. Pharmacological blockade of …

In ancient times, physicians had a limited number of therapies to provide pain relief. Not
surprisingly, plant extracts applied topically often served as the primary analgesic plan. With …

The perception of pain throughout the body arises when neural signals originating from the
terminals of nociceptors are propagated to second-order neurons in the spinal cord or …

Highlights•Neuropathic pain is a chronic condition that represents a major health
problem.•There is a need for new medications with greater efficacy and less adverse …

It is crucial for a living organism to recognize and discern potentially harmful noxious stimuli
from innocuous stimuli to avoid hazards in the environment. However, unnecessary or …

Transient Receptor Potential Vanilloid 1 (TRPV1) is a Ca2+ permeant non-selective cation
channel expressed in a subpopulation of primary afferent neurons. TRPV1 is activated by …

Nociception is the process of transmission of painful signals by nociceptors in the primary
afferent nerve fibers, which specifically respond to noxious stimuli. These noxious stimuli are …

The transient receptor potential vanilloid 1 and ankyrin 1 (TRPV1 and TRPA1, respectively)
channels are members of the TRP superfamily of structurally related, non‐selective cation …