Control of pre-mRNA accumulation by the essential yeast protein Nrd1 requires high-affinity transcript binding and a domain implicated in RNA polymerase II …

EJ Steinmetz, DA Brow - Proceedings of the National …, 1998 - National Acad Sciences
Nrd1 is an essential yeast protein of unknown function that has an RNA recognition motif
(RRM) in its carboxyl half and a putative RNA polymerase II-binding domain, the CTD …

A yeast heterogeneous nuclear ribonucleoprotein complex associated with RNA polymerase II

NK Conrad, SM Wilson, EJ Steinmetz, M Patturajan… - Genetics, 2000 - academic.oup.com
Recent evidence suggests a role for the carboxyl-terminal domain (CTD) of the largest
subunit of RNA polymerase II (pol II) in pre-mRNA processing. The yeast NRD1 gene …

A functional interface at the rDNA connects rRNA synthesis, pre-rRNA processing and nucleolar surveillance in budding yeast

N Leporé, DLJ Lafontaine - PLoS One, 2011 - journals.plos.org
Ribogenesis is a multistep error-prone process that is actively monitored by quality control
mechanisms. How ribosomal RNA synthesis, pre-rRNA processing and nucleolar …

The Saccharomyces cerevisiae Nrd1-Nab3 Transcription Termination Pathway Acts in Opposition to Ras Signaling and Mediates Response to Nutrient Depletion

MM Darby, L Serebreni, X Pan, JD Boeke… - Molecular and cellular …, 2012 - Taylor & Francis
The Saccharomyces cerevisiae Nrd1-Nab3 pathway directs the termination and processing
of short RNA polymerase II transcripts. Despite the potential for Nrd1-Nab3 to affect the …

[HTML][HTML] Regulation of yeast NRD1 expression by premature transcription termination

JT Arigo, KL Carroll, JM Ames, JL Corden - Molecular cell, 2006 - cell.com
The yeast RNA binding proteins Nrd1 and Nab3 are required for termination of
nonpolyadenylated transcripts from RNA polymerase (Pol) II-transcribed snRNA and …

A network of interdependent molecular interactions describes a higher order Nrd1-Nab3 complex involved in yeast transcription termination

TJ Loya, TW O'Rourke, N Degtyareva… - Journal of Biological …, 2013 - ASBMB
Nab3 and Nrd1 are yeast heterogeneous nuclear ribonucleoprotein (hnRNP)-like proteins
that heterodimerize and bind RNA. Genetic and biochemical evidence reveals that they are …

A CBF5 mutation that disrupts nucleolar localization of early tRNA biosynthesis in yeast also suppresses tRNA gene-mediated transcriptional silencing

A Kendall, MW Hull, E Bertrand… - Proceedings of the …, 2000 - National Acad Sciences
In the budding yeast, Saccharomyces cerevisiae, actively transcribed tRNA genes can
negatively regulate adjacent RNA polymerase II (pol II)-transcribed promoters. This tRNA …

Terminating transcription in yeast: whether to be a'nerd'or a'rat'

AG Rondon, HE Mischo, NJ Proudfoot - Nature structural & molecular …, 2008 - nature.com
Transcriptional termination by RNA polymerase II in yeast occurs by two different pathways:
stable or cryptic unstable transcripts use the Nrd1 complex, whereas mRNA uses 3 …

A cotranscriptional model for 3′-end processing of the Saccharomyces cerevisiae pre-ribosomal RNA precursor

AK Henras, E Bertrand, G Chanfreau - Rna, 2004 - rnajournal.cshlp.org
Cleavage of the Saccharomyces cerevisiae primary ribosomal RNA (rRNA) transcript in the
3′ external transcribed spacer (ETS) by Rnt1p generates the 35S pre-rRNA, the earliest …

Repression of gene expression by an exogenous sequence element acting in concert with a heterogeneous nuclear ribonucleoprotein-like protein, Nrd1, and the …

EJ Steinmetz, DA Brow - Molecular and cellular biology, 1996 - Am Soc Microbiol
We have fortuitously identified a nucleotide sequence that decreases expression of a
reporter gene in the yeast Saccharomyces cerevisiae 20-fold when inserted into an intron …