Background There is an ongoing debate about the concept of restricted phenotypes of
amyotrophic lateral sclerosis (ALS), including progressive bulbar palsy (PBP). Objective The …

Background There is an ongoing debate whether primary lateral sclerosis (PLS) should be
regarded as an independent disease entity separate from amyotrophic lateral sclerosis …

Background After the demonstration of a corticoefferent propagation pattern in amyotrophic
lateral sclerosis (ALS) by neuropathological studies, this concept has been used for in vivo …

Background The criteria for assessing upper motor neuron pathology in pure lower motor
neuron disease (LMND) still remain a major issue of debate with respect to the clinical …

Background White matter (WM) impairment is a hallmark of amyotrophic lateral sclerosis
(ALS). This study evaluated the capacity of mean apparent propagator magnetic resonance …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease
that is characterized by a high heterogeneity in patients' disease course. Patients with bulbar …

Background Bulbar dysfunction is a cardinal feature of ALS with important quality of life and
management implications. The objective of this study is the longitudinal evaluation of a large …

The aim of this work was to investigate white-matter microstructural changes within and
outside the corticospinal tract in classical amyotrophic lateral sclerosis (ALS) and in lower …

Introduction Within the core neuroimaging signature of amyotrophic lateral sclerosis (ALS),
the corpus callosum (CC) is increasingly recognized as a consistent feature. The aim of this …

Objective: While the hallmark of amyotrophic lateral sclerosis (ALS) is corticospinal tract in
combination with lower motor neuron degeneration, the clinical involvement of both …