Aim: This study was performed in a sample of the Dutch population to estimate the
prevalence of noncoding mutations of CYP2D6 and CYP2C19 as obtained by genotyping. In …

The polymorphic cytochrome P450 isoenzymes (CYPs) 2C9, 2C19 and 2D6 metabolise
many important drugs, as well as other xenobiotics. Their polymorphism gives rise to …

The aim of the present study was to determine the prevalence of the most common allelic
variants of the polymorphic cytochrome P450 (CYP) enzymes CYP2D6, CYP2C9, CYP2C19 …

Objective. This study investigated the distribution of the CYP2D6 genotypes and phenotypes
in a Polish population and compared the concordance of the two methods. Methods. Six …

Abstract CYP2C19 and CYP2D6 are important drug-metabolizing enzymes that are involved
in the metabolism of around 30% of all medications. Importantly, the corresponding genes …

Introduction: CYP2C19* 17 is a novel variant allele causing ultrarapid metabolism of
CYP2C19 substrates. In the present study we investigated the CYP2C19* 17 allelic …

CYP2D6 is a member of cytochrome P450 enzymes that metabolise over 25% of commonly
used drugs. Genetic polymorphisms can cause insufficient drug efficacy at usually …

Purpose To determine the distribution of clinically important CYP2C genotypes and allele
frequencies in healthy Nordic populations with special focus on linkage disequilibrium …

Aims To investigate the distribution of cytochrome P450 2C9 (CYP2C9) and 2C19
(CYP2C19) genotype frequencies in the Beninese and Belgian Caucasian populations …

Objective The purpose of the study was to study the distribution of poor and extensive
metabolizers of CYP2C19 and CYP2D6 and to genotype for CYP2C8 and CYP2C9 among …