[HTML][HTML] Females exhibit higher GluA2 levels and outperform males in active place avoidance despite increased amyloid plaques in TgF344-Alzheimer's rats
O Chaudry, K Ndukwe, L Xie, M Figueiredo-Pereira… - Scientific Reports, 2022 - nature.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease that is most prevalent
in females. While estrogen provides neuroprotection in females, sex mediated differences in …
in females. While estrogen provides neuroprotection in females, sex mediated differences in …
[HTML][HTML] Sex differences in hippocampal β-amyloid accumulation in the triple-transgenic mouse model of Alzheimer's disease and the potential role of local estrogens
YT Hu, XL Chen, YN Zhang, H McGurran… - Frontiers in …, 2023 - frontiersin.org
Introduction Epidemiological studies show that women have a higher prevalence of
Alzheimer's disease (AD) than men. Peripheral estrogen reduction during aging in women is …
Alzheimer's disease (AD) than men. Peripheral estrogen reduction during aging in women is …
[HTML][HTML] Both male and female APPswe/PSEN1dE9 mice are impaired in spatial memory and cognitive flexibility at 9 months of age
LA Hulshof, LA Frajmund, D van Nuijs… - Neurobiology of …, 2022 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia. Despite many years of
research, very limited treatment options are available. Here we aim to establish a well …
research, very limited treatment options are available. Here we aim to establish a well …
[HTML][HTML] Sex difference in evolution of cognitive decline: studies on mouse model and the Dominantly Inherited Alzheimer Network cohort
RP Kommaddi, A Verma, G Muniz-Terrera… - Translational …, 2023 - nature.com
Women carry a higher burden of Alzheimer's disease (AD) compared to men, which is not
accounted entirely by differences in lifespan. To identify the mechanisms underlying this …
accounted entirely by differences in lifespan. To identify the mechanisms underlying this …
Sex‐specific accelerated decay in time/activity‐dependent plasticity and associative memory in an animal model of Alzheimer's disease
S Navakkode, JR Gaunt, MV Pavon, VA Bansal… - Aging …, 2021 - Wiley Online Library
Clinical studies have shown that female brains are more predisposed to neurodegenerative
diseases such as Alzheimer's disease (AD), but the cellular and molecular mechanisms …
diseases such as Alzheimer's disease (AD), but the cellular and molecular mechanisms …
[HTML][HTML] Estradiol replacement at the critical period protects hippocampal neural stem cells to improve cognition in APP/PS1 mice
Y Qin, D An, W Xu, X Qi, X Wang, L Chen… - Frontiers in Aging …, 2020 - frontiersin.org
It has been suggested that there is a critical window for estrogen replacement therapy (ERT)
in postmenopausal women with Alzheimer's disease (AD); however, supporting evidence is …
in postmenopausal women with Alzheimer's disease (AD); however, supporting evidence is …
Sex differences in behavior and molecular pathology in the 5XFAD model
A Sil, A Erfani, N Lamb, R Copland… - Journal of …, 2022 - content.iospress.com
Background: The prevalence of Alzheimer's disease (AD) is greater in women compared to
men, but the reasons for this remain unknown. This sex difference has been widely …
men, but the reasons for this remain unknown. This sex difference has been widely …
Impaired performance of female APP/PS1 mice in the Morris water maze is coupled with increased Aβ accumulation and microglial activation
JJ Gallagher, AM Minogue, MA Lynch - Neurodegenerative diseases, 2012 - karger.com
Background: Alzheimer's disease (AD) is characterized by progressive neuronal loss and
cognitive decline. Epidemiological studies suggest that the risk of AD is higher in women …
cognitive decline. Epidemiological studies suggest that the risk of AD is higher in women …
Differential alteration of hippocampal function and plasticity in females and males of the APPxPS1 mouse model of Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
memory loss and impaired cognitive functions. The higher incidence of AD among women …
memory loss and impaired cognitive functions. The higher incidence of AD among women …
Exploring the parity paradox: Differential effects on neuroplasticity and inflammation by APOEe4 genotype at middle age
BH Lee, M Cevizci, SE Lieblich, M Ibrahim… - Brain, Behavior, and …, 2024 - Elsevier
Female sex and Apolipoprotein E (APOE) ε4 genotype are top non-modifiable risk factors for
Alzheimer's disease (AD). Although female-unique experiences like parity (pregnancy and …
Alzheimer's disease (AD). Although female-unique experiences like parity (pregnancy and …