[HTML][HTML] The roles of human DNA methyltransferases and their isoforms in shaping the epigenome
A DNA sequence is the hard copy of the human genome and it is a driving force in
determining the physiological processes in an organism. Concurrently, the chemical …
determining the physiological processes in an organism. Concurrently, the chemical …
DNMT1: catalytic and non-catalytic roles in different biological processes
KN Mohan - Epigenomics, 2022 - Taylor & Francis
DNMT1 is the main enzyme that uses the information on DNA methylation patterns in the
parent strand and methylates the daughter strand in freshly replicated hemimethylated DNA …
parent strand and methylates the daughter strand in freshly replicated hemimethylated DNA …
[HTML][HTML] Structural basis of DNMT1 and DNMT3A-mediated DNA methylation
DNA methylation, one of the major epigenetic mechanisms, plays critical roles in regulating
gene expression, genomic stability and cell lineage commitment. The establishment and …
gene expression, genomic stability and cell lineage commitment. The establishment and …
Solving the Dnmt2 enigma
M Schaefer, F Lyko - Chromosoma, 2010 - Springer
Dnmt2 is a member of the animal DNA methyltransferase family of enzymes. While the role
of other Dnmt proteins has been extensively characterized, comparably little is known about …
of other Dnmt proteins has been extensively characterized, comparably little is known about …
[HTML][HTML] DNMT3B functions: novel insights from human disease
M Gagliardi, M Strazzullo… - Frontiers in cell and …, 2018 - frontiersin.org
DNA methylation plays important roles in gene expression regulation and chromatin
structure. Its proper establishment and maintenance are essential for mammalian …
structure. Its proper establishment and maintenance are essential for mammalian …
[HTML][HTML] DNA methyl transferase 1: regulatory mechanisms and implications in health and disease
S Dhe-Paganon, F Syeda, L Park - International journal of …, 2011 - ncbi.nlm.nih.gov
DNA methylation serves as the principal form of post-replicative epigenetic modification. It is
intricately involved in gene regulation and silencing in eukaryotic cells, making significant …
intricately involved in gene regulation and silencing in eukaryotic cells, making significant …
The de novo DNA methyltransferase DNMT3A in development and cancer
BF Chen, WY Chan - Epigenetics, 2014 - Taylor & Francis
DNA methylation, one of the best-characterized epigenetic modifications, plays essential
roles in development, aging and diseases. The de novo DNA methyltransferase DNMT3A is …
roles in development, aging and diseases. The de novo DNA methyltransferase DNMT3A is …
An insight into the various regulatory mechanisms modulating human DNA methyltransferase 1 stability and function
DNA methylation is one of the principal epigenetic signals that participate in cell specific
gene expression in vertebrates. DNA methylation plays a quintessential role in the control of …
gene expression in vertebrates. DNA methylation plays a quintessential role in the control of …
Allosteric control of mammalian DNA methyltransferases–a new regulatory paradigm
A Jeltsch, RZ Jurkowska - Nucleic acids research, 2016 - academic.oup.com
In mammals, DNA methylation is introduced by the DNMT1, DNMT3A and DNMT3B
methyltransferases, which are all large multi-domain proteins containing a catalytic C …
methyltransferases, which are all large multi-domain proteins containing a catalytic C …
Structure and function of mammalian DNA methyltransferases
DNA methylation plays an important role in epigenetic signalling, having an impact on gene
regulation, chromatin structure, development and disease. Here, we review the structures …
regulation, chromatin structure, development and disease. Here, we review the structures …