Background: SERCA [sarco (endo) plasmic reticulum calcium ATPase] is regulated by
oxidative posttranslational modifications at cysteine 674 (C674). Because sarcoplasmic …

Despite advances in cardioprotection, new therapeutic strategies capable of preventing
ischemia-reperfusion injury of patients are still needed. Here, we discover that sarcoplasmic …

Reduced sarco (endo) plasmic reticulum (SR) Ca2+ ATPase (SERCA2) contributes to the
impaired cardiomyocyte Ca2+ homeostasis observed in heart failure. We hypothesized that …

The sarco (endo) plasmic reticulum calcium ATPase 2 (SERCA2) transports Ca2+ from
cytosol into the sarcoplasmic reticulum (SR) of cardiomyocytes, thereby maintaining the …

Abstract Sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase 2 (SERCA2) is vital to maintain
intracellular calcium homeostasis, and its redox Cys 674 (C674) is the key to regulating …

Background—Reduced sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA2a isoform)
activity is a major determinant of reduced contractility in heart failure. Ca2+-ATPase …

Endothelial cells lining the microvasculature are particularly vulnerable to the deleterious
effects of cardiac ischemia/reperfusion (I/R) injury, a susceptibility that is partially mediated …

Among the new players at the endoplasmic reticulum (ER)-mitochondria interface regulating
interorganelle calcium signaling, those specifically involved during ER stress are not known …

Ca+ mishandling due to impaired activity of cardiac sarco (endo) plasmic reticulum Ca2+
ATPase (SERCA2a) has been associated with the development of left ventricular diastolic …

Background A hallmark of aging of the cardiac myocyte is impaired sarcoplasmic reticulum
(SR) calcium uptake and relaxation due to decreased SR calcium ATP ase (SERCA) activity …