The antigen-specific activation of pathogenic T cells is considered essential in the initiation
and maintenance of multiple sclerosis (MS). The site of activation, the differential …

Objective Multiple sclerosis (MS) is a disease of the central nervous system with marked
heterogeneity in several aspects including pathological processes. Based on infiltrating …

Patients with multiple sclerosis (MS) show a high prevalence of myelin-reactive CD8+ and
CD4+ T-cell responses, which are the putative effectors/modulators of CNS neuropathology …

Background Multiple sclerosis (MS), an autoimmune disease of the central nervous system
(CNS), can be suppressed in its early stages but eventually becomes clinically progressive …

Objective In multiple sclerosis (MS), central nervous system (CNS), cerebrospinal fluid
(CSF), and blood display TCR clonal expansions of CD 8+ T cells. These clones have been …

T cells provide critical immune surveillance to the central nervous system (CNS), and the
cerebrospinal fluid (CSF) is thought to be a main route for their entry. Further …

Objectives: To characterize phenotypes of T cells that accumulated in multiple sclerosis (MS)
lesions, to compare the lesional T-cell receptor (TCR) repertoire of T-cell subsets to …

T cells and B cells are crucial in the initiation and maintenance of multiple sclerosis (MS),
and the activation of these cells is believed to be mediated through specific recognition of …

Epstein‐Barr virus (EBV) has long been suggested as a pathogen in multiple sclerosis (MS).
Here, we used high‐throughput sequencing to determine the diversity …

Circulating and tissue-resident T cells collaborate in the protection of tissues against harmful
infections and malignant transformation but also can instigate autoimmune reactions. Similar …