The aim of this study, evaluate the nociceptive effect of adalimumab, a TNF-alpha inhibitor,
on formalin-induced inflammatory pain in mice. The antinociceptive activity of adalimumab …

Sirolimus is an immunosupressive drug that specifically inhibit the activation of T-
lymphocytes. This study was undertaken to investigate whether treatment with sirolimus …

Objective The reduction of pain in the course of antiinflammatory therapy can result from an
attenuation of the inflammatory process and/or from the neutralization of endogenous …

Objective: The main objectives of the present work are to determine the clinical effect of
niranthin on visceral or somatic inflammatory pain. The study was performed to determine …

This study evaluated the effects of different anti-TNFα strategies on the nociceptive and
inflammatory responses triggered by formalin in the rat orofacial region. Formalin injection …

Aims Ibuprofen arginate is a highly soluble salt formed by combining racemic ibuprofen with
the amino acid l-arginine. This formulation is absorbed faster, and it is safe and effective in …

Background: Nitric oxide (NO) is involved in the transmission and modulation of nociceptive
information at the peripheral, spinal cord and supraspinal levels. We conducted this …

Study Design. An experimental animal study. Objective. To study if antitumor necrosis factor-
alpha (TNF-α) antibody, which is administered at different times, reduces the pain behavior …

Recent studies have revealed that T lymphocytes play a role in neuropathic pain following
nerve injury in rats through releasing several cytokines. Sirolimus is an immunosuppressive …

Introduction Tumor necrosis factor-alpha (TNFα) inhibitors have significantly improved the
outcomes of treatment for rheumatoid arthritis (RA). In the present study, we aimed to …