Abstract Changes in glycosylation during tumour progression are a key hallmark of cancer.
One of the glycan moieties generally overexpressed in cancer are sialic acids, which can …

Abstract Changes in sialic acids in cancer have been observed for many years. In particular,
the increase of sialoglycan density or hypersialylation in tumors has been described. Recent …

Simple Summary Hyperglycosylated cancer cells are often decorated with abundant sialic
acids, which are recognized by Sialic acid binding immunoglobulin type lectins (Siglecs) …

Sialic acids represent a family of sugar molecules derived from neuraminic acid that
frequently terminate glycan chains and contribute to many biological processes. Already five …

Sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of receptors that
recognize sialoglycans–sialic acid containing glycans that are abundantly present on cell …

Introduction: During cancer progression, tumor cells develop several mechanisms to prevent
killing and to shape the immune system into a tumor-promoting environment. One of such …

Sialic acid sugar-carrying glycans, sialoglycans, are aberrantly expressed on many tumor
cells and have emerged as potent regulatory molecules involved in creating a tumor …

Siglecs (sialic acid–binding immunoglobulin-like lectins) are a family of receptors that bind
sialic acids in specific linkages on glycoproteins and glycolipids. Siglecs play roles in …

The Siglecs (sialic acid-binding immunoglobulin-like lectins) are glycoimmune checkpoint
receptors that suppress immune cell activation upon engagement of cognate sialoglycan …

Sialic acid sugars on the surface of cancer cells have emerged as potent immune
modulators that contribute to the immunosuppressive microenvironment and tumor immune …