Kisspeptin, originally identified as metastatin, important in preventing cancer metastasis, has
more recently been shown to be important in pregnancy. Roles indicated for kisspeptin in …

Kisspeptin is a neuropeptide with a critical role in the function of the hypothalamic–pituitary–
gonadal (HPG) axis. Kisspeptin is produced by two major populations of neurons located in …

Context: Mutation of the G protein-coupled receptor 54 is associated with a failure of
reproductive function. The endogenous neuropeptide agonist for G protein-coupled receptor …

Changes in metabolic status gate reproductive activity by still incompletely deciphered
mechanisms. Many neuropeptides have been shown to be involved in restraining …

Kisspeptins are a family of neuropeptides that are critical for the puberty initiation and female
fertility. Plasma or serum kisspeptin is mainly derived from the placenta during pregnancy …

It is well established that reproductive function is metabolically gated. However, the
mechanisms whereby energy stores and metabolic cues influence fertility are yet to be …

Body energy balance and metabolic signals are important modulators of puberty and
reproductive function, so that perturbations of metabolism and energy reserves (ranging …

Background Kisspeptin is involved in female reproduction. This study was designed to i-
estimate kisspeptin levels in women with polycystic ovary syndrome (PCOS), in comparison …

Context: Kisspeptin, the endogenous ligand of the G protein-coupled receptor 54, is a key
regulator of the hypothalamo-pituitary-gonadal (HPG) axis. GPR54-null mice exhibit …

Background and aims Spexin (SPX) is a novel peptide recently discovered as an important
regulatory adipokine in obesity and related metabolic diseases. The aim of the current study …