Myostatin (MSTN), a negative regulator of muscle growth and size, is increased after acute
myocardial infarction (AMI) but timing of upregulation after injury is not known. In this study …

Background Myostatin inhibits the development of skeletal muscle and regulates the
proliferation of skeletal muscle fibroblasts. However, the role of myostatin in regulating …

Myostatin (Mst) is a negative regulator of skeletal muscle in humans and animals. It is
moderately expressed in the heart of sheep and cattle, increasing considerably after …

Myostatin is well established as a negative regulator of skeletal muscle growth, but its role in
the heart is controversial. Our goal in this study was to characterize myostatin regulation …

Myostatin is a highly conserved, potent negative regulator of skeletal muscle hypertrophy in
many species, from rodents to humans, although its mechanisms of action are incompletely …

Although myostatin negatively regulates skeletal muscle growth, its function in heart is
virtually unknown. Herein we demonstrate that it inhibits basal and IGF‐stimulated …

Ischemia reperfusion (IR) injury plays a pivotal role in many diseases and leads to collateral
damage during surgical interventions. While most studies focus on alleviating its severity in …

Abstract Background Myostatin (Mstn) is a key regulator of heart metabolism and
cardiomyocyte growth interacting tightly with insulin-like growth factor I (IGF-I) under …

Background—Cardiac cachexia is characterized by an exaggerated loss of skeletal muscle,
weakness, and exercise intolerance, although the cause of these effects remains unknown …

Myostatin, a member of the TGF-β superfamily of secreted growth factors, is a negative
regulator of skeletal muscle growth. In the heart, it is expressed at lower levels compared to …