Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is increasingly
viewed as a complex multi-dimensional disease without effective treatments. Recent …

Irreversible acetylcholinesterase (AChE) inhibition accumulates to high levels in the central
nervous system (CNS) because AChE turnover in the brain is much slower than in …

Abstract Alzheimer's disease (AD), the most common cause of adult-onset dementia is
characterized by a progressive decline of cognitive functions accompanied by behavioral …

Acetylcholinesterase inhibitors (AChEIs) are generally regarded as palliative treatments for
Alzheimer's disease that slow the progression of dementia symptoms without altering …

Alzheimer's Diseases (AD) is a neurodegenerative disorder characterized by progressive
neuronal loss leading to cognitive decline. Although there is yet to be a cure nor a way to …

Alzheimer's disease (AD) is a neurodegenerative disease characterized by memory and
cognitive loss, and represents the leading cause of dementia in elderly people. Besides the …

Alzheimer's disease is the most prevalent late-onset neurodegenerative disorder of
unknown origin. The cholinergic hypothesis of Alzheimer's disease attributes the cognitive …

Decades of research have produced no effective method to prevent, delay the onset, or slow
the progression of Alzheimer's disease (AD). In contrast to these failures …

Acetylcholinesterase inhibitors (AChEIs) have been shown to produce a small, but
significant, improvement in cognition in patients with Alzheimer's disease. However, not all …

Since the 1980s, the cholinergic hypothesis of the pathogenesis of Alzheimer's disease has
proven to be a strong stimulus to pharmacological strategies aimed at correcting the …