Macrophages within solid tumors and metastatic sites are heterogenous populations with
different developmental origins and substantially contribute to tumor progression. A number …

Macrophages have emerged as promising therapeutic targets in cancer. Within tumor tissue,
macrophages foster tumor development, invasion, and metastasis. As the phenotype of …

Tumor-associated macrophages are one of the major constituents of tumor stroma in many
solid tumors and there is compelling preclinical and clinical evidence that macrophages …

Macrophages are innate immune cells with evolutionarily conserved functions in tissue
maintenance and host defense. As such, macrophages are among the first hematopoietic …

Macrophages are found in all tissues and display outstanding functional diversity. From
embryo to birth and throughout adult life, they play critical roles in development …

Macrophages are present in all vertebrate tissues and have emerged as multifarious cells
with complex roles in development, tissue homeostasis, and disease. Macrophages are a …

Macrophages are multi-functional innate immune cells that occupy normal or pathologic
tissues, including cancer tissues. The importance of macrophage ontogeny and the …

The tumor microenvironment is a complex ecology of cells that evolves with and provides
support to tumor cells during the transition to malignancy. Among the innate and adaptive …

Evading immune destruction and tumor promoting inflammation are important hallmarks in
the development of cancer. Macrophages are present in most human tumors and are often …

Macrophages are a specialized class of innate immune cells with multifaceted roles in
modulation of the inflammatory response, homeostasis, and wound healing. While …