Evidence from observational studies and randomized trials suggests that prediabetes and
type 2 diabetes mellitus (T2DM) can develop in genetically susceptible individuals in …

Introduction: Insulin resistance (IR) and pancreatic beta-cell dysfunction are core
pathophysiologic features of type 2 diabetes mellitus (T2DM). Select lifestyle and …

Background: Individuals with impaired fasting glucose or impaired glucose tolerance are at
high risk of progression to type 2 diabetes. Lifestyle modification through change to diet and …

A series of large-scale randomised controlled trials have demonstrated the effectiveness of
lifestyle change in preventing type 2 diabetes in people with impaired glucose tolerance …

Type 1 diabetes is a challenging condition to manage for various physiological and
behavioural reasons. Regular exercise is important, but management of different forms of …

Around 80% of individuals with Type 1 diabetes (T1D) in the United States do not achieve
glycaemic targets and the prevalence of comorbidities suggests that novel therapeutic …

BACKGROUND The number of people with diabetes mellitus worldwide is expected to
increase from 120 million today to approximately 300 million by 2025. Although the …

Type 2 diabetes mellitus is an important preventable disease and a growing public health
problem. Epidemiologic and interventional studies suggest that weight loss is the main …

▪ Abstract In recent years, the prevalence of type 2 diabetes has increased alarmingly
worldwide, giving diabetes the dimension of an epidemic. Striking parallel increases in the …

The worldwide prevalence of type 2 diabetes mellitus is increasing at a rapid rate,
predominantly because of changes in environmental factors interacting with individual …