Gap junctions (GJ) and connexins play integral roles in cellular physiology and have been
found to be involved in multiple pathophysiological states from cancer to cardiovascular …

Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

Intercellular co-operation is a fundamental and widespread feature in tissues and organs.
An important mechanism ensuring multicellular homoeostasis involves signalling between …

Connexins, in particular connexin 43 (Cx43), function as gap junction channels (GJCs) and
hemichannels (HCs). Only recently, specific tools have been developed to study their …

There is a dearth of chemical inhibitors of connexin-mediated intercellular communication.
The advent of short “designer” connexin mimetic peptides has provided new tools to inhibit …

Gap junctions and their connexin components are indispensable in mediating the cellular
coordination required for tissue and organ homeostasis. The critical nature of their existence …

Cells of multicellular organisms need to communicate and have evolved different
mechanisms of intercellular communication, the most direct and quickest of which is through …

The connexin family of channel-forming proteins is present in every tissue type in the human
anatomy. Connexins are best known for forming clustered intercellular channels, structurally …

Connexins have been proposed as a target for therapeutic treatment of a variety of
conditions. The main approaches have been by antisense or small peptides specific against …

Connexins form gap junctions that function as intercellular channels and hemichannels that
form a conduit between the cytoplasm and extracellular fluid when open. Peptide inhibitors …