[HTML][HTML] Biomarkers of cetuximab resistance in patients with head and neck squamous cell carcinoma

O Leblanc, S Vacher, C Lecerf, E Jeannot… - Cancer Biology & …, 2020 - ncbi.nlm.nih.gov
Objective: In patients with head and neck squamous cell carcinoma (HNSCC), cetuximab [a
monoclonal antibody targeting epidermal growth factor receptor (EGFR)] has been shown to …

Cetuximab in locally advanced head and neck squamous cell carcinoma: Biological mechanisms involved in efficacy, toxicity and resistance

E Muraro, G Fanetti, V Lupato, V Giacomarra… - Critical Reviews in …, 2021 - Elsevier
Since its introduction, the use of cetuximab in the treatment of head and neck squamous cell
carcinoma (HNSCC) has experienced an evolution. Currently, cetuximab associated with …

Spotlight on cetuximab in squamous cell carcinoma of the head and necky

JE Frampton - BioDrugs, 2011 - Springer
Cetuximab (Erbitux®) is a chimeric monoclonal antibody directed against the human
epidermal growth factor receptor (EGFR). EGFR is overexpressed and/or upregulated in …

mTOR Co-Targeting in Cetuximab Resistance in Head and Neck Cancers Harboring PIK3CA and RAS Mutations

Z Wang, D Martin, AA Molinolo, V Patel… - Journal of the …, 2014 - academic.oup.com
Background Cetuximab, a monoclonal blocking antibody against the epidermal growth
factor receptor EGFR, has been approved for the treatment of squamous cell carcinomas of …

Mechanism of acquired resistance to cetuximab in head and neck cancer.

A Khattri, N Sheikh, R Acharya, YHC Tan, S Kochanny… - 2018 - ascopubs.org
e18061 Background: Cetuximab, a monoclonal antibody against EGFR, is the only
approved targeted therapy for head and neck squamous cell carcinoma (HNSCC), with a …

Cetuximab: a review of its use in squamous cell carcinoma of the head and neck

JE Frampton - Drugs, 2010 - Springer
Cetuximab (Erbitux®) is a chimeric monoclonal antibody directed against the human
epidermal growth factor receptor (EGFR). EGFR is overexpressed and/or upregulated in …

[HTML][HTML] A patient-derived somatic mutation in the epidermal growth factor receptor ligand-binding domain confers increased sensitivity to cetuximab in head and neck …

EM Bahassi, YQ Li, TM Wise-Draper, L Deng… - European Journal of …, 2013 - Elsevier
BACKGROUND: Cetuximab is an epidermal growth factor receptor (EGFR)-blocking
antibody that has been approved for the treatment of patients with head and neck squamous …

[HTML][HTML] Phase I study of ficlatuzumab and cetuximab in cetuximab-resistant, recurrent/metastatic head and neck cancer

JE Bauman, J Ohr, WE Gooding, RL Ferris, U Duvvuri… - Cancers, 2020 - mdpi.com
Cetuximab, an anti-EGFR monoclonal antibody (mAb), is approved for advanced head and
neck squamous cell carcinoma (HNSCC) but benefits a minority. An established tumor …

Cetuximab in the treatment of head and neck cancer

J Bernier - Expert review of anticancer therapy, 2006 - Taylor & Francis
Approaches to the treatment of locally advanced and recurrent and/or metastatic squamous
cell carcinoma of the head and neck (SCCHN) have been limited by their toxicity. Effective …

Cetuximab: a review of its use in squamous cell carcinoma of the head and neck and metastatic colorectal cancer

SKA Blick, LJ Scott - Drugs, 2007 - Springer
Cetuximab (Erbitux®) is a human-mouse chimeric monoclonal antibody, which competitively
binds to the accessible extracellular domain of the epidermal growth factor receptor (EGFR) …