[HTML][HTML] Biomarkers of cetuximab resistance in patients with head and neck squamous cell carcinoma
O Leblanc, S Vacher, C Lecerf, E Jeannot… - Cancer Biology & …, 2020 - ncbi.nlm.nih.gov
Objective: In patients with head and neck squamous cell carcinoma (HNSCC), cetuximab [a
monoclonal antibody targeting epidermal growth factor receptor (EGFR)] has been shown to …
monoclonal antibody targeting epidermal growth factor receptor (EGFR)] has been shown to …
Cetuximab in locally advanced head and neck squamous cell carcinoma: Biological mechanisms involved in efficacy, toxicity and resistance
E Muraro, G Fanetti, V Lupato, V Giacomarra… - Critical Reviews in …, 2021 - Elsevier
Since its introduction, the use of cetuximab in the treatment of head and neck squamous cell
carcinoma (HNSCC) has experienced an evolution. Currently, cetuximab associated with …
carcinoma (HNSCC) has experienced an evolution. Currently, cetuximab associated with …
Spotlight on cetuximab in squamous cell carcinoma of the head and necky
JE Frampton - BioDrugs, 2011 - Springer
Cetuximab (Erbitux®) is a chimeric monoclonal antibody directed against the human
epidermal growth factor receptor (EGFR). EGFR is overexpressed and/or upregulated in …
epidermal growth factor receptor (EGFR). EGFR is overexpressed and/or upregulated in …
mTOR Co-Targeting in Cetuximab Resistance in Head and Neck Cancers Harboring PIK3CA and RAS Mutations
Background Cetuximab, a monoclonal blocking antibody against the epidermal growth
factor receptor EGFR, has been approved for the treatment of squamous cell carcinomas of …
factor receptor EGFR, has been approved for the treatment of squamous cell carcinomas of …
Mechanism of acquired resistance to cetuximab in head and neck cancer.
e18061 Background: Cetuximab, a monoclonal antibody against EGFR, is the only
approved targeted therapy for head and neck squamous cell carcinoma (HNSCC), with a …
approved targeted therapy for head and neck squamous cell carcinoma (HNSCC), with a …
Cetuximab: a review of its use in squamous cell carcinoma of the head and neck
JE Frampton - Drugs, 2010 - Springer
Cetuximab (Erbitux®) is a chimeric monoclonal antibody directed against the human
epidermal growth factor receptor (EGFR). EGFR is overexpressed and/or upregulated in …
epidermal growth factor receptor (EGFR). EGFR is overexpressed and/or upregulated in …
[HTML][HTML] A patient-derived somatic mutation in the epidermal growth factor receptor ligand-binding domain confers increased sensitivity to cetuximab in head and neck …
EM Bahassi, YQ Li, TM Wise-Draper, L Deng… - European Journal of …, 2013 - Elsevier
BACKGROUND: Cetuximab is an epidermal growth factor receptor (EGFR)-blocking
antibody that has been approved for the treatment of patients with head and neck squamous …
antibody that has been approved for the treatment of patients with head and neck squamous …
[HTML][HTML] Phase I study of ficlatuzumab and cetuximab in cetuximab-resistant, recurrent/metastatic head and neck cancer
Cetuximab, an anti-EGFR monoclonal antibody (mAb), is approved for advanced head and
neck squamous cell carcinoma (HNSCC) but benefits a minority. An established tumor …
neck squamous cell carcinoma (HNSCC) but benefits a minority. An established tumor …
Cetuximab in the treatment of head and neck cancer
J Bernier - Expert review of anticancer therapy, 2006 - Taylor & Francis
Approaches to the treatment of locally advanced and recurrent and/or metastatic squamous
cell carcinoma of the head and neck (SCCHN) have been limited by their toxicity. Effective …
cell carcinoma of the head and neck (SCCHN) have been limited by their toxicity. Effective …
Cetuximab: a review of its use in squamous cell carcinoma of the head and neck and metastatic colorectal cancer
SKA Blick, LJ Scott - Drugs, 2007 - Springer
Cetuximab (Erbitux®) is a human-mouse chimeric monoclonal antibody, which competitively
binds to the accessible extracellular domain of the epidermal growth factor receptor (EGFR) …
binds to the accessible extracellular domain of the epidermal growth factor receptor (EGFR) …
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