The regulatory role of estrogens and nuclear estrogen receptors, ie, estrogen receptor α and
β has been reported in gastrointestinal diseases. However, the contribution of G protein …

Estrogen is an important sex steroid hormone which serves an important role in the
regulation of a number of biological functions, including regulating bone density, brain …

Estrogens play important roles in the development and progression of multiple tumor types.
Accumulating evidence points to the significance of estrogen action not only in tumors of …

Objectives: Estrogen is suggested to participate in pathogenesis of irritable bowel syndrome
(IBS), but expression of G protein-coupled estrogen receptor (GPER) in the colon of IBS …

Background Diarrhea‐predominant irritable bowel syndrome (IBS‐D) is a functional
gastrointestinal (GI) disorder, which occurs more frequently in women than men. The aim of …

Estrogen has a pivotal role in many biological functions in both reproductive and non-
reproductive organs, mediating actions through its receptors, estrogen receptor?(ER?) and …

Estrogens exert immunomodulatory action in many autoimmune diseases. Accumulating
evidence highlights the meaningful impact of estrogen receptors in physiology and …

G protein–coupled estrogen receptor (GPER) might be involved in ulcerative colitis (UC), but
the direct effect of GPER on UC is still unclear. We used male C57BL/6 mice to establish the …

The pathogenesis of inflammatory bowel diseases (IBD) seems to be associated with
alterations of immunoregulation. Several lines of evidence suggest that estrogens play a …

The etiology and pathogenesis underlying irritable bowel syndrome (IBS), a common
gastrointestinal disorder are still unclear. Cumulating data suggest dysregulation of …