Estrogen and progesterone receptors: from molecular structures to clinical targets

S Ellmann, H Sticht, F Thiel, MW Beckmann… - Cellular and Molecular …, 2009 - Springer
Research involving estrogen and progesterone receptors (ER and PR) have greatly
contributed to our understanding of cell signaling and transcriptional regulation. In addition …

Expression of estrogen receptors in gastric cancer and their clinical significance

WS Ryu, JH Kim, YJ Jang, SS Park… - Journal of surgical …, 2012 - Wiley Online Library
Abstract Backgrounds and Objectives The male predominance of gastric cancer suggests
that female sex hormones may have a protective effect against gastric cancer. We evaluated …

What pharmacologists can learn from recent advances in estrogen signalling

JÅ Gustafsson - Trends in pharmacological sciences, 2003 - cell.com
The discovery of the second estrogen receptor (ER) in 1995 surprised many
endocrinologists and resulted in some scepticism regarding its physiological importance …

GPER: An Estrogen Receptor Key in Metastasis and Tumoral Microenvironments

AC Tirado-Garibay, EA Falcón-Ruiz… - International Journal of …, 2023 - mdpi.com
Estrogens and their role in cancer are well-studied, and some cancer types are classified in
terms of their response to them. In recent years, a G protein-coupled estrogen receptor …

A novel estrogen receptor GPER mediates proliferation induced by 17β‐estradiol and selective GPER agonist G‐1 in estrogen receptor α (ERα)‐negative ovarian …

H Liu, Y Yan, H Wen, X Jiang, X Cao… - Cell Biology …, 2014 - Wiley Online Library
G protein‐coupled estrogen receptor (GPER) is recently identified as a membrane‐
associated estrogen receptor that mediates non‐genomic effects of estrogen. Our previous …

Estrogen-related receptor alpha in select host functions and cancer: new frontiers

HS Ranhotra - Molecular and Cellular Biochemistry, 2022 - Springer
Eukaryotic gene expression is under the tight control of transcription factors, which includes
the estrogen-related receptor alpha (ERRα). The endogenous ligand (s) acting as ERRα …

[HTML][HTML] Targeting the G protein-coupled estrogen receptor (GPER) in obesity and diabetes

G Sharma, ER Prossnitz - Endocrine and metabolic science, 2021 - Elsevier
Obesity has become a global epidemic in the modern world with the numbers of obese
individuals having risen at alarming rates in the last decades. Obesity represents a serious …

Uterine glycolytic enzyme expression is affected by knockout of different estrogen receptor subtypes

M Hu, Y Zhang, E Egecioglu, X Li… - Biomedical …, 2019 - spandidos-publications.com
The estrogen signaling pathway via nuclear estrogen receptors (ER) α and β is considered
to be the master regulator of the cellular glucose metabolism in the uterus. While in vivo …

[HTML][HTML] The putative G-protein coupled estrogen receptor agonist G-1 suppresses proliferation of ovarian and breast cancer cells in a GPER-independent manner

C Wang, X Lv, C Jiang, JS Davis - American journal of translational …, 2012 - ncbi.nlm.nih.gov
G-protein coupled estrogen receptor 1 (GPER) plays an important role in mediating estrogen
action in many different tissues under both physiological and pathological conditions. G-1 (1 …

[PDF][PDF] Immunolocalization of estrogen receptor alpha and beta in gastric epithelium and enteric neurons

M Campbell-Thompson, KK Reyher… - Journal of …, 2001 - academia.edu
A sexual dimorphism in gastric acid secretion has been known for many years, with women
secreting less acid (40%) than men. The mechanisms mediating this sex difference are …