Apigenin-loaded galactose tailored PLGA nanoparticles: A possible strategy for liver targeting to treat hepatocellular carcinoma

S Ganguly, S Dewanjee, R Sen… - Colloids and Surfaces B …, 2021 - Elsevier
Hepatocellular carcinoma (HCC) is the most common hepatic malignancy worldwide.
Recent reports focusing on the efficacy of apigenin-loaded nanoparticles (NPs) in combating …

Targeting liver cancer via ASGP receptor using 5-FU-loaded surface-modified PLGA nanoparticles

R Dangi, P Hurkat, A Jain, S Shilpi, A Jain… - Journal of …, 2014 - Taylor & Francis
Context: Liver cancer is widespread liver malignancy in the world, for an estimated one
million deaths annually. Objective: In present work, lactobionic acid conjugated PLGA …

Gambogic acid-loaded PEG–PCL nanoparticles act as an effective antitumor agent against gastric cancer

D Zhang, Z Zou, W Ren, H Qian, Q Cheng… - Pharmaceutical …, 2018 - Taylor & Francis
Poor water solubility and side effects hampered the clinical application of gambogic acid
(GA) in cancer therapy. Accordingly, GA-loaded polyethylene glycol-poly (ɛ …

Surface-modified PLGA nanoparticles with PEG/LA-chitosan for targeted delivery of arsenic trioxide for liver cancer treatment: Inhibition effects enhanced and side …

X Song, J Wang, Y Xu, H Shao, J Gu - Colloids and Surfaces B …, 2019 - Elsevier
Abstract Arsenic trioxide (As 2 O 3), an effective drug for leukemia, is limited to be used for
solid tumor treatment due to its high side effects. In this study, polyethylene glycol (PEG) and …

Lactobionic acid-conjugated TPGS nanoparticles for enhancing therapeutic efficacy of etoposide against hepatocellular carcinoma

A Tsend-Ayush, X Zhu, Y Ding, J Yao, L Yin… - …, 2017 - iopscience.iop.org
Many effective anti-cancer drugs have limited use in hepatocellular carcinoma (HCC)
therapy due to the drug resistance mechanisms in liver cells. In recent years, tumor-targeted …

Functional alginate nanoparticles for efficient intracellular release of doxorubicin and hepatoma carcinoma cell targeting therapy

H Guo, Q Lai, W Wang, Y Wu, C Zhang, Y Liu… - International journal of …, 2013 - Elsevier
In order to efficiently deliver chemotherapy drugs into hepatoma cells, a pH-sensitive and
liver-targeted drug delivery system (glycyrrhetinic acid-modified alginate/doxorubicin …

Tannic acid and vitamin E loaded PLGA nanoparticles ameliorate hepatic injury in a chronic alcoholic liver damage model via EGFR-AKT-STAT3 pathway

S Nag, K Manna, M Saha, K Das Saha - Nanomedicine, 2020 - Taylor & Francis
Aim: Tannic acid and vitamin E loaded-poly D, L-lactide-co-glycolic acid (PLGA)
nanoparticles (NP) were developed to achieve hepatoprotection in alcoholic liver disease …

[HTML][HTML] The effect of encapsulated apigenin nanoparticles on HePG-2 cells through regulation of P53

MM Mabrouk Zayed, HA Sahyon, NAN Hanafy… - Pharmaceutics, 2022 - mdpi.com
Apigenin (Ap) is one of the most important natural flavonoids that has potent anticancer
activity. This study was designed, for the first time, to load Ap into chitosan to improve its …

Apocynin-loaded PLGA nanomedicine tailored with galactosylated chitosan intrigue asialoglycoprotein receptor in hepatic carcinoma: prospective targeted therapy

HM Anter, RM Aman, DIA Othman, KM Elamin… - International Journal of …, 2023 - Elsevier
Nature serves as a priceless source for phytomedicines to treat different types of cancer,
including hepatocellular carcinoma (HCC). Apocynin (APO), an anti-cancer phytomedicine …

Formulation, characterization and evaluation of curcumin-loaded PLGA-TPGS nanoparticles for liver cancer treatment

X Chen, Y Li, Y Zhang, G Li - Drug design, development and …, 2019 - Taylor & Francis
Background Liver cancer is a major health problem facing mankind. Currently, the focus of
research is to improve the treatment of liver cancer using a variety of treatment options such …