Motor neuron disease (MND) is a rare group of disorders characterized by degeneration of
motor neurons (MNs). The most common form of MND, amyotrophic lateral sclerosis (ALS) …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder affecting upper
and lower motor neurons (MNs) that still lacks an efficacious therapy. The failure of recent …

Objective: Neurofilaments in CSF are promising biomarkers which might help in the
diagnosis of motor neuron disease (MND). We aim to assess the diagnostic value of …

Elevated cerebrospinal fluid (CSF), Neurofilament Light (NF-L) and phosphorylated Heavy
(pNF-H) chain levels have been found in Amyotrophic Lateral Sclerosis (ALS), with studies …

There is a need for biomarkers for amyotrophic lateral sclerosis (ALS), to support the
diagnosis of the disease, to predict disease progression and to track disease activity and …

Neuroaxonal damage is a feature of various neurodegenerative diseases including
amyotrophic lateral sclerosis (ALS). Phosphorylated neurofilament heavy chain (pNfH) is a …

Neurofilament levels are elevated in many neurodegenerative diseases and have shown
promise as diagnostic and prognostic biomarkers in Amyotrophic Lateral Sclerosis (ALS) …

Background To allow early diagnosis and monitoring of disease progression, there is a need
for biomarkers in amyotrophic lateral sclerosis (ALS). Neurofilaments (NF) are emerging …

Objectives: Elevated neurofilament light chain (NFL) levels within the cerebrospinal fluid
(CSF) are a biomarker representing axonal neurodegeneration in rapid progressive …

This study aims to determine the serum and cerebrospinal fluid (CSF) levels of
neurofilament light chain (NFL) and phosphorylated neurofilament heavy chain (pNFH) in …