Background Different resistance mechanisms for multidrug-resistant tuberculosis (MDR-TB)
and extensively drug-resistant tuberculosis (XDR-TB) have been reported. Although …

Background Among different resistance mechanisms in Mycobacterium tuberculosis (MTB),
efflux pumps may have a role in drug-resistance property of MTB. So, the aim of this study …

Objectives Active extrusion of antituberculosis drugs via efflux pumps (EPs) has been
suggested as contributing to drug resistance in Mycobacterium tuberculosis. This study was …

Introduction Extensively drug-resistant tuberculosis (XDR-TB) has emerged as one of the
biggest threats to public health and TB control programs worldwide. XDR-TB is caused by …

In this study, we used molecular and proteomic methods to detect novel changes within drug-
resistant tuberculosis (TB) strains. Our goal was to detect changes within efflux pump (EP) …

Currently, drug resistance is a formidable obstacle to tuberculosisprevention globally. A
deep understanding of the drug-resistance mechanism of Mycobacterium tuberculosis is …

Finding a gene or genes that are involved with multidrug resistance will be useful for finding
a new target for the treatment of drug resistant tuberculosis. In this study, we aimed to …

Introduction: Tuberculosis (TB) remains a serious public health problem worldwide. Drug-
resistant TB is considered a major and growing global threat. Despite the great variety of …

Isoniazid (INH) and rifampicin (RIF) are the two most effective drugs in tuberculosis therapy.
Understanding the molecular mechanisms of resistance to these two drugs is essential to …

It is challenging to understand mechanisms of drug resistance in Mycobacterium
tuberculosis (MTB) due to the large variability in resistance associated genes. Efflux pump …