[PDF][PDF] γ-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO
RA Koeth, BS Levison, MK Culley, JA Buffa, Z Wang… - Cell metabolism, 2014 - cell.com
L-carnitine, a nutrient in red meat, was recently reported to accelerate atherosclerosis via a
metaorganismal pathway involving gut microbial trimethylamine (TMA) formation and host …
metaorganismal pathway involving gut microbial trimethylamine (TMA) formation and host …
[HTML][HTML] l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans
RA Koeth, BR Lam-Galvez, J Kirsop… - The Journal of …, 2019 - Am Soc Clin Investig
BACKGROUND. l-Carnitine, an abundant nutrient in red meat, accelerates atherosclerosis
in mice via gut microbiota–dependent formation of trimethylamine (TMA) and trimethylamine …
in mice via gut microbiota–dependent formation of trimethylamine (TMA) and trimethylamine …
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
RA Koeth, Z Wang, BS Levison, JA Buffa, E Org… - Nature medicine, 2013 - nature.com
Intestinal microbiota metabolism of choline and phosphatidylcholine produces
trimethylamine (TMA), which is further metabolized to a proatherogenic species …
trimethylamine (TMA), which is further metabolized to a proatherogenic species …
Gut microbiota metabolism of L-carnitine and cardiovascular risk
JR Ussher, GD Lopaschuk, A Arduini - Atherosclerosis, 2013 - Elsevier
In recent years, a number of studies have alluded to the importance of the intestinal
microflora in controlling whole-body metabolic homeostasis and organ physiology. In …
microflora in controlling whole-body metabolic homeostasis and organ physiology. In …
Suppression of intestinal microbiota-dependent production of pro-atherogenic trimethylamine N-oxide by shifting L-carnitine microbial degradation
J Kuka, E Liepinsh, M Makrecka-Kuka, J Liepins… - Life sciences, 2014 - Elsevier
Abstract Aims Trimethylamine-N-oxide (TMAO) is produced in host liver from trimethylamine
(TMA). TMAO and TMA share common dietary quaternary amine precursors, carnitine and …
(TMA). TMAO and TMA share common dietary quaternary amine precursors, carnitine and …
The microbial gbu gene cluster links cardiovascular disease risk associated with red meat consumption to microbiota l-carnitine catabolism
JA Buffa, KA Romano, MF Copeland, DB Cody… - Nature …, 2022 - nature.com
The heightened cardiovascular disease (CVD) risk observed among omnivores is thought to
be linked, in part, to gut microbiota-dependent generation of trimethylamine-N-oxide (TMAO) …
be linked, in part, to gut microbiota-dependent generation of trimethylamine-N-oxide (TMAO) …
Elucidation of an anaerobic pathway for metabolism of l-carnitine–derived γ-butyrobetaine to trimethylamine in human gut bacteria
LJ Rajakovich, B Fu, M Bollenbach… - Proceedings of the …, 2021 - National Acad Sciences
Trimethylamine (TMA) is an important gut microbial metabolite strongly associated with
human disease. There are prominent gaps in our understanding of how TMA is produced …
human disease. There are prominent gaps in our understanding of how TMA is produced …
The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis
K Skagen, M Trøseid, T Ueland, S Holm, A Abbas… - Atherosclerosis, 2016 - Elsevier
Background and purpose γ-butyrobetaine (γBB) is a metabolite from dietary Carnitine,
involved in the gut microbiota-dependent conversion from Carnitine to the pro-atherogenic …
involved in the gut microbiota-dependent conversion from Carnitine to the pro-atherogenic …
Major increase in microbiota-dependent proatherogenic metabolite TMAO one year after bariatric surgery
M Trøseid, JR Hov, TK Nestvold… - … syndrome and related …, 2016 - liebertpub.com
Abstract Background: Trimethylamine-N-oxide (TMAO) is formed in the liver from
trimethylamine (TMA), a product exclusively generated by the gut microbiota from dietary …
trimethylamine (TMA), a product exclusively generated by the gut microbiota from dietary …
[HTML][HTML] L-Carnitine intake and high trimethylamine N-oxide plasma levels correlate with low aortic lesions in ApoE−/− transgenic mice expressing CETP
HL Collins, D Drazul-Schrader, AC Sulpizio, PD Koster… - Atherosclerosis, 2016 - Elsevier
Objective Dietary l-carnitine can be metabolized by intestinal microbiota to trimethylamine,
which is absorbed by the gut and further oxidized to trimethylamine N-oxide (TMAO) in the …
which is absorbed by the gut and further oxidized to trimethylamine N-oxide (TMAO) in the …